Inhibition of experimental abdominal aortic aneurysm in a rat model by the angiotensin receptor blocker valsartan
Inhibition of experimental abdominal aortic aneurysm in a rat model by the angiotensin receptor blocker valsartan
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DOI：
10.3892/ijmm_00000075
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发表时间：
2008-12-01
影响因子：
5.4
通讯作者：
Morishita, Ryuichi
中科院分区：
文献类型：
--
作者：
Fujiwara, Yoshikazu;Shiraya, Suguru;Morishita, Ryuichi
Angiotensin (Ang) II exerts direct effects on the arterial wall to influence atherosclerosis and aneurysm development with the induction of vascular inflammation. Therefore, we examined the hypothesis that the inhibition of Ang II would decrease the expansion of abdominal aortic aneurysm (AAA) in a rat model. We used the Ang II receptor blocker (ARB) valsartan to inhibit the effect of Ang II. Additionally. we employed a dosage of valsartan (1 mg/kg/day) that does not affect blood pressure, to avoid the effect of blood pressure lowering. Notably. progression of elastase-induced AAA was inhibited in rats treated with valsartan (P
