Basic and Translational Research in Cardiac Repair and Regeneration: JACC State-of-the-Art Review.
Basic and Translational Research in Cardiac Repair and Regeneration: JACC State-of-the-Art Review.
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心脏修复和再生中的基础和翻译研究：JACC最新研究综述。
DOI：
10.1016/j.jacc.2021.09.019
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发表时间：
2021-11-23
影响因子：
24
通讯作者：
Dzau, Victor J.
中科院分区：
文献类型：
--
作者：
Zhang, Jianyi;Bolli, Roberto;Garry, Daniel J.;Marban, Eduardo;Menasche, Philippe;Zimmermann, Wolfram-Hubertus;Kamp, Timothy J.;Wu, Joseph C.;Dzau, Victor J.
本文旨在提供使用细胞治疗策略和工程化心脏组织治疗心肌梗死后左室重构和心力衰竭的临床前和临床试验的重要进展。除了作者自己的工作和对该领域障碍的看法外，他们还讨论了通过激活驻留心肌细胞的增殖机制或直接将体细胞重新编程为心肌细胞来实现心肌重塑的新方法。本文的主要思路是根据它们对未来患者试验设计的影响提出当前和未来的策略，最终目标是促进再生心肌疗法的发现转化为临床。
This paper aims to provide an important update on the recent preclinical and clinical trials using cell therapy strategies and engineered heart tissues for the treatment of postinfarction left ventricular remodeling and heart failure. In addition to the authors’ own works and opinions on the roadblocks of the field, they discuss novel approaches for cardiac remuscularization via the activation of proliferative mechanisms in resident cardiomyocytes or direct reprogramming of somatic cells into cardiomyocytes. This paper’s main mindset is to present current and future strategies in light of their implications for the design of future patient trials with the ultimate objective of facilitating the translation of discoveries in regenerative myocardial therapies to the clinic.
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影响因子：
5.9
作者：
Aminzadeh MA;Rogers RG;Fournier M;Tobin RE;Guan X;Childers MK;Andres AM;Taylor DJ;Ibrahim A;Ding X;Torrente A;Goldhaber JM;Lewis M;Gottlieb RA;Victor RA;Marbán E
通讯作者：
Marbán E
影响因子：
23.9
作者：
Burridge, Paul W.;Keller, Gordon;Gold, Joseph D.;Wu, Joseph C.
通讯作者：
Wu, Joseph C.
影响因子：
15.9
作者：
Didie, Michael;Christalla, Peter;Zimmermann, Wolfram-Hubertus
通讯作者：
Zimmermann, Wolfram-Hubertus
影响因子：
5.2
作者：
Gnecchi, Massimiliano;He, Huamei;Melo, Luis G.;Noiseaux, Nicolas;Morello, Fulvio;de Boer, Rudolf A.;Zhang, Lunan;Pratt, Richard E.;Dzau, Victor J.;Ingwall, Joanne S.
通讯作者：
Ingwall, Joanne S.
影响因子：
20.1
作者：
Agarwal U;George A;Bhutani S;Ghosh-Choudhary S;Maxwell JT;Brown ME;Mehta Y;Platt MO;Liang Y;Sahoo S;Davis ME
通讯作者：
Davis ME