Shaping the intestinal brush border.
Shaping the intestinal brush border.
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DOI:
10.1083/jcb.201407015
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发表时间:
2014-11-24
期刊:
影响因子:
--
通讯作者:
Tyska MJ
中科院分区:
文献类型:
--
作者:
Crawley SW;Mooseker MS;Tyska MJ
Epithelial cells from diverse tissues, including the enterocytes that line the intestinal tract, remodel their apical surface during differentiation to form a brush border: an array of actin-supported membrane protrusions known as microvilli that increases the functional capacity of the tissue. Although our understanding of how epithelial cells assemble, stabilize, and organize apical microvilli is still developing, investigations of the biochemical and physical underpinnings of these processes suggest that cells coordinate cytoskeletal remodeling, membrane-cytoskeleton cross-linking, and extracellular adhesion to shape the apical brush border domain.
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