Shaping the intestinal brush border.

Shaping the intestinal brush border.
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DOI:
10.1083/jcb.201407015
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发表时间:
2014-11-24
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Tyska MJ
Tyska MJ
中科院分区:
其他
文献类型:
--
作者:
Crawley SW;Mooseker MS;Tyska MJ

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来自不同组织的上皮细胞,包括肠道内的肠上皮细胞,在分化过程中重塑其顶端表面,形成刷状缘:一系列肌动蛋白支持的膜突起,称为微绒毛,可增加组织的功能能力。尽管我们对上皮细胞如何组装、稳定和组织顶端微绒毛的理解仍在发展中,但对这些过程的生化和物理基础的研究表明,细胞协调细胞骨架重塑、膜-细胞骨架交联和细胞外粘附来塑造顶端刷状缘域。
Epithelial cells from diverse tissues, including the enterocytes that line the intestinal tract, remodel their apical surface during differentiation to form a brush border: an array of actin-supported membrane protrusions known as microvilli that increases the functional capacity of the tissue. Although our understanding of how epithelial cells assemble, stabilize, and organize apical microvilli is still developing, investigations of the biochemical and physical underpinnings of these processes suggest that cells coordinate cytoskeletal remodeling, membrane-cytoskeleton cross-linking, and extracellular adhesion to shape the apical brush border domain.
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