A versatile ultrafine and super-absorptive H(+)-modified montmorillonite: application for metabolic syndrome intervention and gastric mucosal protection.
A versatile ultrafine and super-absorptive H(+)-modified montmorillonite: application for metabolic syndrome intervention and gastric mucosal protection.
复制标题
一种多功能超细、高吸收性H()改性蒙脱石：用于代谢综合征干预和胃粘膜保护的应用。
DOI：
10.1039/d0bm00474j
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Tang Guping
中科院分区：
文献类型：
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作者：
Wang Qiwen;Shen Jie;Mo Enqi;Zhang Haotian;Wang Jianwei;Hu Xiurong;Zhou Jun;Bai Hongzhen;Tang Guping
代谢综合征（MetS）包括向心性肥胖、高血压、胰岛素抵抗和血脂异常，与非酒精性脂肪肝、动脉粥样硬化性心血管疾病（CVD）和2型糖尿病密切相关，涉及多种致病因素。目前用于干预和改善MetS的药物疗法在代谢疾病的临床治疗中是必不可少的。在本报告中，我们提出了一种采用酸改性方法制备的H+改性蒙脱土（H-MMT），具有超细结构和超强吸收能力，作为治疗MetS的潜在药物。以高脂饮食喂养的仓鼠经口给予H-MMT，辛伐他汀作为对照。蒙脱土通过减少肠道吸收、促进脂质排泄来降低血脂，从而预防肥胖、脂肪肝和高脂血症。此外，与辛伐他汀相比，H-MMT明显更安全，肝脏耐受性更好，辛伐他汀具有肝毒性。此外，我们发现H-MMT对胃粘膜损伤有保护作用。因此，这种多功能的H-MMT提供了一种潜在的策略，以有效地改善代谢综合征，并在临床应用中提供胃粘膜保护。
Metabolic syndrome (MetS) includes central obesity, hypertension, insulin resistance, and dyslipidemia and is closely related to nonalcoholic fatty liver disease, atherosclerotic cardiovascular disease (CVD) and type 2 diabetes mellitus, involving multiple causative factors. Current drug therapies for intervention and amelioration of MetS are essential in clinical treatment of metabolic disease. In this report, we proposed an H+-modified montmorillonite (H-MMT) using an acid modification method with ultrafine structure and super absorption ability as a potential drug for MetS. Hamsters fed a high-fat diet were orally treated with H-MMT and simvastatin was applied as a control. H-MMT lowered lipids by decreasing intestinal absorption and promoting lipid excretion, subsequently preventing obesity, fatty liver, and hyperlipidemia. Moreover, H-MMT was significantly safer and better tolerated by the liver compared to simvastatin, which was hepatotoxic. In addition, we found that H-MMT had protective effects on gastric mucosal damage. Therefore, this versatile H-MMT provides a potential strategy to effectively improve MetS and provide gastric mucosal protection in clinical applications.