Change detection in regional and volumetric disc parameters using longitudinal confocal scanning laser tomography.
Change detection in regional and volumetric disc parameters using longitudinal confocal scanning laser tomography.
复制标题
使用纵向共焦扫描激光断层扫描检测区域和体积椎间盘参数的变化。
DOI：
10.1016/s0161-6420(01)01005-3
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发表时间：
2002
期刊：
影响因子：
13.7
通讯作者：
Thompson,HilaryW
中科院分区：
文献类型：
--
作者：
Burgoyne,ClaudeF;Mercante,DonaldE;Thompson,HilaryW
目的：开发一种针对纵向采集的共焦扫描激光断层扫描 (CSLT) 图像中视神经乳头 (ONH) 表面变化检测的临床具体策略。设计：实验研究。参与者和/或对照：十二只猴子，每只一只患有青光眼的眼睛，一只对侧正常的眼睛。主要观察指标：检测每只猴子青光眼的 CSLT 图像中 ONH 表面的变化。方法：在 3 天（成像过程）内，从 12 只猴子的双眼获得六张 10° 和六张 15° CSLT 图像和四张立体视盘照片，然后每两周在一只眼睛（研究眼）进行激光以升高眼压后获得。对于每只眼睛的每组 10° 和 15° 图像（以及每只猴子 7-25 个成像会话中的每一个），计算了 37 个 CSLT 参数。单变量变化要求单个参数的变化超过其方差分析确定的最小可检测变化 (MDC) 值。多变量变化需要三个参数组一起考虑，以证明通过多变量方差分析确定的显着变化。每个单独参数和一组三参数组合的假阳性变化检测率是在 12 只不变的对侧正常眼的激光后图像中使用连续策略（在单个会话中发生变化）和连续两策略（在两个连续会话中发生变化）来确定的。然后，仅针对临床特异性的单个参数和三参数组合（即，正常眼睛中的假阳性变化检测率低于 10%）评估研究眼睛图像内的变化检测。结果：总共进行了 36 次激光前成像（每只猴子 3 次）和 158 次激光后成像（每只猴子 4-22 次）。仅通过连续两策略才能实现临床特异性变化检测（低误报率）。总体而言，多变量 ONH 表面变化检测表现最好；表现最好的三参数组合在对侧正常眼的激光后成像会话中的 139 个成像会话中仅检测到 8 个变化事件（4 个发作和 4 个进展），而在 12 个研究眼睛的激光成像会话中总共检测到 47 个变化事件（11 个发作和 36 个进展）。在研究眼睛的后期激光成像过程中，在终末期损伤之后，大多数参数都发生了违反直觉的（前部）变化。结论：在纵向采集的 CSLT 图像中，可以对青光眼 ONH 表面变化的发生和进展进行临床特异性检测。
PURPOSE: To develop a clinically specific strategy for optic nerve head (ONH) surface change detection within longitudinally acquired confocal scanning laser tomographic (CSLT) images. DESIGN: Experimental study. PARTICIPANTS AND/OR CONTROLS: Twelve monkeys, each with one glaucomatous and one contralateral normal eye. MAIN OUTCOME MEASURES: Detection of ONH surface change within the CSLT images of each monkey’s glaucomatous eye. METHODS: Six 10° and six 15° CSLT images and four stereo optic disc photographs were obtained from both eyes of 12 monkeys on 3 separate days (imaging sessions) and then every 2 weeks after laser to one eye (study eye) to elevate intraocular pressure. For each set of 10° and 15° images per eye (and for each of the 7–25 imaging sessions per monkey), 37 CSLT parameters were calculated. Univariate change required an individual parameter to change in excess of its analysis of variance-determined minimum detectable change (MDC) value. Multivariate change required groups of three parameters, considered together, to demonstrate significant change as determined by a multivariate analysis of variance. The rate of false-positive change detection for each individual parameter and for a group of three-parameter combinations was determined using both a one-in-a-row strategy (change at a single session) and a two-in-a-row strategy (change at two successive sessions) within the postlaser images of the 12 unchanging contralateral normal eyes. Change detection within the study eye images was then assessed for only those individual parameters and three-parameter combinations that were clinically specific (i.e., showed less than 10% false-positive change detection in the normal eyes). RESULTS: A total of 36 prelaser (three per monkey) imaging sessions and 158 postlaser (4–22/monkey) imaging sessions was performed. Clinically specific change detection (low rate of false positives) was achieved only with the two-in-a-row strategy. Overall, multivariate ONH surface change detection performed best; the best-performing three-parameter combination detected only 8 change events (4 onset and 4 progression) in 139 imaging sessions within the postlaser imaging sessions of the contralateral normal eyes and a total of 47 change events (11 onset and 36 progression) within the postlaser imaging sessions of the 12 study eyes. Counterintuitive (anterior) change occurred in most parameters within the late postlaser imaging sessions of the study eyes followed to end-stage damage. CONCLUSIONS: Clinically specific detection of the onset and progression of glaucomatous ONH surface change is possible within longitudinally acquired CSLT images.