In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model.
In vivo testing of porous Ti-25Nb alloy serving as a femoral stem prosthesis in a rabbit model.
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多孔 Ti-25Nb 合金作为股骨假体的兔模型体内测试
DOI：
10.3892/etm.2016.3472
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发表时间：
2016-09
影响因子：
2.7
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Weng X;Yang H;Xu J;Li X;Liao Q;Wang J
本研究旨在观察不同孔隙率的Ti-25 Nb合金作为股骨柄假体在兔模型上的性能，为多孔假体的开发提供基础实验依据。根据髓腔形态设计多孔Ti-25 Nb合金假体。将这些假体置入36只新西兰白色家兔的股骨髓腔内。术后行X线片、种植体界面扫描电镜（SEM）、种植体表面能谱（EDS）分析、拔出试验和一般观察。材料具有良好的生物相容性，X线片显示不同孔隙率的多孔Ti-25 Nb材料在不同时间点均未见明显的骨吸收。扫描电镜下观察到孔隙内及骨与假体界面有钙沉积。EDS分析表明，术后8周时，假体表面存在钙沉积。拔出试验显示骨与种植体之间结合强度良好，拔出后假体表面及孔隙内均呈现骨量。多孔Ti-25 Nb合金植入物具有良好的生物相容性，并在骨和植入物之间提供生物固定。70%的孔隙率更有利于新生骨长入，同时实现更坚固的骨-植入物界面。
The aim of the present study was to observe the performance of Ti-25Nb alloys with various porosities as femoral stem prostheses in a rabbit model, thus providing basic experimental evidence for the development of porous prostheses. The porous Ti-25Nb alloy prostheses were designed according to the morphology of the medullary cavity. These prostheses were placed into the femoral medullary cavities in 36 New Zealand white rabbits. Postoperative X-ray films, scanning electron microscopy (SEM) of the implant interface, energy-dispersive spectroscopy (EDS) analysis of the implant surface, pulling-out test and general observations were conducted. The specimens showed good biocompatibility; there was no obvious bone absorption in porous Ti-25Nb specimens with different porosities at different time points observed using X-ray films. Under SEM examination, calcium deposits were observed inside the pores and in the interface between bone and prostheses. The EDS analysis demonstrated that calcium deposits were present on the surface of the prostheses at the eight-week point postoperatively. The pulling-out test showed good bonding strength between bone and implant; after pulling out, the surface and inside the pores of the prostheses all presented bone mass. Porous Ti-25Nb alloy implants presents good biocompatibility as well as providing a biological fixation between the bone and implant. A porosity of 70% is more advantageous to the newborn bone ingrowth, combined with achieving a more solid bone-implant interface.