BIODEGRADABLE STARCH MICROSPHERES FOR CEREBRAL ARTERIAL EMBOLIZATION
BIODEGRADABLE STARCH MICROSPHERES FOR CEREBRAL ARTERIAL EMBOLIZATION
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DOI：
10.1097/00004424-199302000-00014
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发表时间：
1993-02-01
影响因子：
6.7
通讯作者：
MERLAND, JJ
中科院分区：
文献类型：
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作者：
LACCOURREYE, O;LAURENT, A;MERLAND, JJ
原理和说明。各种材料已被用于头颈部肿瘤和血管畸形的脑内和颈动脉栓塞。这项初步的前瞻性研究旨在分析使用可生物降解淀粉微球进行脑动脉栓塞的临床和组织病理学结果。设计了一种新的动脉栓塞术，可确保颈总动脉和颈内动脉的完整性，而不改变动脉血流。该程序允许在20只Sprague-Dawley大鼠中进行脑动脉微栓塞。通过左颈外动脉将不同量的可生物降解淀粉微球（Spherex）引入脑内。临床和组织病理学结果表明：1）使用生物可降解淀粉微球进行脑栓塞的结果与栓塞材料的量有关; 2）Spherex微球在脑中的行为与可降解微球不同。尽管该材料具有快速的生物降解性，但注意到缺血对大脑的永久性损伤。
RATIONALE AND OBJECTIVES. Various materials have been used to perform intracerebral and cervical arterial embolization for head and neck tumors and vascular malformations. This preliminary prospective study was designed to analyze the clinical and histopathologic consequences of arterial embolization into the brain using biodegradable starch microspheres.METHODS. A new arterial embolization procedure which ensured the integrity of the common and internal carotid arteries, without modifying the arterial flow, was designed. The procedure allowed for cerebral arterial microembolization in 20 Sprague-Dawley rats. Various amounts of biodegradable starch microspheres (Spherex) were introduced into the brain via the left external carotid artery.RESULTS AND CONCLUSIONS. Clinical and histopathologic results suggested that: 1) consequences of cerebral embolization using biodegradable starch microspheres are related to the amount of material embolized; and 2) Spherex microspheres behave differently from degradable microspheres in the brain. Despite the rapid biodegradability of the material, permanent damage from ischemia to the brain was noted.