Development of tissue scaffolds using selective laser sintering of polyvinyl alcohol/hydroxyapatite biocomposite for craniofacial and joint defects
Development of tissue scaffolds using selective laser sintering of polyvinyl alcohol/hydroxyapatite biocomposite for craniofacial and joint defects
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DOI：
10.1023/b:jmsm.0000046393.81449.a5
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发表时间：
2004-10-01
影响因子：
3.7
通讯作者：
Cheah, CM
中科院分区：
文献类型：
--
作者：
Chua, CK;Leong, KF;Cheah, CM
在颅面和关节缺损的修复和替换中，对支架引导的组织工程（TE）以引导和支持细胞增殖的兴趣日益增长，引起了对创建这种支架的精确技术的追求。传统的基于手工的制造技术具有若干限制，例如缺乏再现性和精度。快速成型（RP）已被确定为一种有前途的技术，能够建立具有预定义的宏观和微观结构的复杂对象。研究的重点是使用选择性激光烧结（SLS）RP技术创建TE支架的可行性。将聚乙烯醇（PVA）与羟基磷灰石（HA）共混制成生物复合材料，并将其应用于SLS中，研究其作为支架材料的可行性。将通过喷雾干燥技术和物理混合获得的生物复合材料混合物进行激光烧结以制备测试样品。SLS制造的测试样本，其特征在于使用扫描电子显微镜和X射线衍射。还通过将样本浸入模拟体液环境中测试了测试样本的生物活性。所获得的结果确定SLS制造的支架具有良好的TE应用潜力。(C)2004 Kluwer Academic Publishers.
The growing interest in scaffold-guided tissue engineering (TE) to guide and support cell proliferation in the repair and replacement of craniofacial and joint defects gave rise to the quest for a precise technique to create such scaffolds. Conventional manual-based fabrication techniques have several limitations such as the lack of reproducibility and precision. Rapid prototyping (RP) has been identified as a promising technique capable of building complex objects with pre-defined macro- and microstructures. The research focussed on the viability of using the selective laser sintering (SLS) RP technique for creating TE scaffolds. A biocomposite blend comprising of polyvinyl alcohol (PVA) and hydroxyapatite (HA) was used in SLS to study the feasibility of the blend to develop scaffolds. The biocomposite blends obtained via spray-drying technique and physical blending were subjected to laser-sintering to produce test specimens. The SLS-fabricated test specimens were characterized using scanning electron microscopy and X-ray diffraction. The test specimens were also tested for bioactivity by immersing the samples in simulated body fluid environment. The results obtained ascertained that SLS-fabricated scaffolds have good potential for TE applications. (C) 2004 Kluwer Academic Publishers.