Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine
Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine
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DOI：
10.1016/s0264-410x(02)00076-2
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发表时间：
2002-05-06
期刊：
影响因子：
5.5
通讯作者：
Robinson, HL
中科院分区：
文献类型：
--
作者：
Amara, RR;Villinger, F;Robinson, HL
异源启动/增强方案具有提高高水平免疫反应的潜力。在这里，我们报告了DNA引物和重组修饰的安卡拉牛痘（rMVA）增强剂在恒河猴模型中控制了高致病性免疫缺陷病毒的攻击。疫苗的DNA和rMVA成分均表达多种免疫缺陷病毒蛋白。在0周和8周接种两次DNA，在24周接种一次rMVA增强剂，可有效控制增强剂接种7个月后的直肠内感染。这些非常有希望的发现提供了一个相对简单的多蛋白DNA/MVA疫苗可以帮助控制艾滋病流行的希望。(C) 2002 Elsevier Science Ltd.版权所有。
Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here, we report that DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster has controlled a highly pathogenic immunodeficiency virus challenge in a Rhesus macaque model. Both the DNA and rMVA components of the vaccine expressed multiple immunodeficiency virus proteins. Two DNA inoculations at 0 and 8 weeks and a single rMVA booster at 24 weeks effectively controlled an intrarectal challenge administered 7 months after the booster. These highly promising findings provide hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the AIDS epidemic. (C) 2002 Elsevier Science Ltd. All rights reserved.