Antitumor activity of 2-amino-4,4alpha-dihydro-4alpha, 7-dimethyl-3H-phenoxazine-3-one against Meth A tumor transplanted into BALB/c mice.
Antitumor activity of 2-amino-4,4alpha-dihydro-4alpha, 7-dimethyl-3H-phenoxazine-3-one against Meth A tumor transplanted into BALB/c mice.
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2-氨基-4,4α-二氢-4α,7-二甲基-3H-吩恶嗪-3-酮对移植到 BALB/c 小鼠体内的 Meth A 肿瘤的抗肿瘤活性。
DOI：
10.1097/00001813-200009000-00010
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发表时间：
2000
影响因子：
2.3
通讯作者：
A. Tomoda
中科院分区：
文献类型：
--
作者：
H. Mori;K. Honda;R. Ishida;T. Nohira;A. Tomoda
我们检查了 2-氨基-4,4α-二氢-4α,7-二甲基-3H-吩恶嗪-3-一 (Phx) 对移植到 BALB/c 小鼠体内的 Meth A 癌细胞的体内作用，包括抗肿瘤活性和副作用。 Phx 是通过 2-氨基-5-甲基苯酚与牛溶血产物反应合成的，通过腹腔注射给药。以 1 和 5 mg/kg 的剂量给予移植有 Meth A 肿瘤细胞的 BALB/c 小鼠。 Phx 与 5-氟尿嘧啶 (5-FU) 一样，对小鼠体内生长的 Meth A 肿瘤具有很强的抗肿瘤活性。 5 mg/kg 剂量的 Phx 的抗肿瘤活性与 7.8 mg/kg 剂量的 5-FU 相当。相比之下，与5-FU不同的是，Phx不会引起白细胞减少，同时表现出很强的抗肿瘤活性。该化合物对体重的影响也很小，并且没有出现小鼠消瘦的情况。这些结果表明Phx具有很强的抗肿瘤活性，但副作用较低，表明Phx在未来可用于治疗目的。
We examined the in vivo effect of 2-amino-4,4alpha-dihydro-4alpha,7-dimethyl-3H-phenoxazine-3- one (Phx) on Meth A carcinoma cells transplanted into BALB/c mice, in terms of both antitumor activity and side effects. Phx, which was synthesized by the reaction of 2-amino-5-methylphenol with bovine hemolysates, was administered i.p. at doses of 1 and 5 mg/kg to BALB/c mice transplanted with Meth A tumor cells. Phx exerted a strong antitumor activity to Meth A tumor growing in the mice as 5-fluorouracil (5-FU) did. The antitumor activity of Phx at the dose of 5 mg/kg was comparable to that of 5-FU at the dose of 7.8 mg/kg. In contrast, unlike 5-FU, Phx did not cause leukopenia while showing a strong antitumor activity. The compound also produced little changes in body weight and no wasting of mice developed. These results show that Phx has strong anti-tumor activity, but exerts lower side effects and suggest that Phx is available for therapeutic purposes in the future.
影响因子：
2.9
作者：
F. Takusagawa;L. Wen;W. Chu;Q. Li;K. T. Takusagawa;R. G. Carlson;R. F. Weaver
通讯作者：
F. Takusagawa;L. Wen;W. Chu;Q. Li;K. T. Takusagawa;R. G. Carlson;R. F. Weaver
7-碳原子被氮丙啶和氨基丙氧基取代的放线菌素 D 发色类似物的合成和生物学特性。
影响因子：
7.3
作者：
Sehgal,RK;Almassian,B;Rosenbaum,DP;Zadrozny,R;Sengupta,SK
通讯作者：
Sengupta,SK