A broken circadian clock: The emerging neuro-immune link connecting depression to cancer.
A broken circadian clock: The emerging neuro-immune link connecting depression to cancer.
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破裂的昼夜节律：新兴的神经免疫连接将抑郁症与癌症联系起来。
DOI：
10.1016/j.bbih.2022.100533
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发表时间：
2022-12
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生物钟协调许多生物体的日常节奏，对最佳健康至关重要。昼夜节律破坏事件，如时差，轮班工作，夜间暴露和时钟基因改变，引起病理条件，包括癌症和临床抑郁症。本文系统地介绍了生物钟的基本机制以及生物钟与癌症和抑郁症之间的相互作用关系。我们认为，这个破碎的时钟是一个新兴的联系，连接抑郁症和癌症的发展。重要的是，打破生物钟，癌症和抑郁症形成了一个恶性反馈循环，威胁到全身健康。通过恢复正常的昼夜节律来阻止这种有害循环是治疗癌症和抑郁症的潜在治疗策略。
Circadian clocks orchestrate daily rhythms in many organisms and are essential for optimal health. Circadian rhythm disrupting events, such as jet-lag, shift-work, night-light exposure and clock gene alterations, give rise to pathologic conditions that include cancer and clinical depression. This review systemically describes the fundamental mechanisms of circadian clocks and the interacting relationships among a broken circadian clock, cancer and depression. We propose that this broken clock is an emerging link that connects depression and cancer development. Importantly, broken circadian clocks, cancer and depression form a vicious feedback loop that threatens systemic fitness. Arresting this harmful loop by restoring normal circadian rhythms is a potential therapeutic strategy for treating both cancer and depression.