Connections between the zona incerta and superior colliculus in the monkey and squirrel.
Connections between the zona incerta and superior colliculus in the monkey and squirrel.
复制标题
猴子和松鼠的未定带和上丘之间的连接。
DOI：
10.1007/s00429-017-1503-2
复制
发表时间：
2018
影响因子：
3.1
通讯作者：
Basso,MicheleA
中科院分区：
文献类型：
--
作者：
May,PaulJ;Basso,MicheleA
猫和大鼠的不明地带含有GABA能神经元，这些神经元投射到上丘，这表明它在凝视变化中发挥了作用。然而，这种内在联系是否代表了哺乳动物的一般模式仍有待确定。我们使用神经元示踪剂来检查灰松鼠和猕猴中脑顶盖与未确定带的联系。在两种动物的结肠注射中，大多数顶盖下层神经元位于腹侧层，但在背侧层和腹侧层都发现了顺行标记的顶盖端部终末。在猴子身上，顶盖前的注射也产生了逆行标记，但主要是在背层。顶盖细胞和顶盖细胞的树突区一般位于它们的体细胞所在的层内。猕猴，而不是松鼠，在外髓板内向背侧延伸。注射Incerta可在两种动物的上丘产生逆行标记的神经元。在松鼠中，大多数细胞分布在中间灰质层的下层，而在猴子中，它们散布在更深的层中。在两种动物的顶盖前核中均有标记细胞。两种动物的标记终末均集中在中间灰层的下层亚层，但散在顶盖前核之间。综上所述，集中在丘脑运动输出层的、起源于同侧未定带腹侧层的膝状体投射是哺乳动物的一种常见特征，提示它在丘脑功能中起重要作用。
The zona incerta contains GABAergic neurons that project to the superior colliculus in the cat and rat, suggesting that it plays a role in gaze changes. However, whether this incertal connection represents a general mammalian pattern remains to be determined. We used neuronal tracers to examine the zona incerta connections with the midbrain tectum in the gray squirrel and macaque monkey. Collicular injections in both species revealed that most incertotectal neurons lay in the ventral layer, but anterogradely labeled tectoincertal terminals were found in both the dorsal and ventral layers. In the monkey, injections of the pretectum also produced retrograde labeling, but mainly in the dorsal layer. The dendritic fields of incertotectal and incertopretectal cells were generally contained within the layer inhabited by their somata. The macaque, but not the squirrel, zona incerta extended dorsolaterally, within the external medullary lamina. Zona incerta injections produced retrogradely labeled neurons in the superior colliculus of both species. In the squirrel, most cells inhabited the lower sublamina of the intermediate gray layer, but in the monkey, they were scattered throughout the deeper layers. Labeled cells were present among the pretectal nuclei in both species. Labeled terminals were concentrated in the lower sublamina of the intermediate gray layer of both species, but were dispersed among the pretectal nuclei. In summary, an incertal projection that is concentrated on the collicular motor output layers and that originates in the ventral layer of the ipsilateral zona incerta is a common mammalian feature, suggesting an important role in collicular function.