Preclinical study of boron neutron capture therapy for bone metastasis using human breast cancer cell lines
Preclinical study of boron neutron capture therapy for bone metastasis using human breast cancer cell lines
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DOI：
10.1016/j.apradiso.2020.109257
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发表时间：
2020-11-01
影响因子：
1.6
通讯作者：
Ichikawa, Hideki
中科院分区：
文献类型：
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作者：
Andoh, Tooru;Fujimoto, Takuya;Ichikawa, Hideki
骨转移对生活质量有重大影响，常规治疗无法控制。我们用人乳腺癌细胞系建立了骨转移模型，并研究了硼中子俘获疗法（BNCT）的治疗效果。对于髓内小肿瘤，BNCT在不损伤正常组织的情况下抑制了肿瘤生长，初步证明它是一种控制骨转移肿瘤生长的潜在新治疗选择。其临床应用还需要进一步研究。
Bone metastasis has a major impact on the quality of life that general therapy cannot control. We established a bone metastasis model with a human breast cancer cell line and investigated the therapeutic effect of boron neutron capture therapy (BNCT). BNCT suppressed tumor growth in cases of intramedullary small tumors without damaging normal tissues, providing preliminary evidence that it is a potentially new therapeutic option for controlling tumor growth from bone metastasis. Further research is warranted for its clinical application.