GENERALIZED CYTOMEGALIC INCLUSION DISEASE
GENERALIZED CYTOMEGALIC INCLUSION DISEASE
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DOI：
10.1016/s0022-3476(50)80097-5
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发表时间：
1950-01-01
影响因子：
5.1
通讯作者：
PINKERTON, H
中科院分区：
文献类型：
--
作者：
WYATT, JP;SAXTON, J;PINKERTON, H
本文描述了六例婴儿巨细胞包涵体病的致命病例。该系列包括1例死胎和5例14个月以下的婴儿。这些内含物是在豚鼠唾液腺中发现的类型，在相当大比例的正常婴儿中也是如此，但在所讨论的病例中，它们广泛分布于全身，特别是在肺、肝和肾中，所产生的病变严重到足以被视为死亡原因。这些病例被诊断为紫癜、百日咳、肠炎和支气管肺炎，正确的诊断是在死后才作出的。本文详细介绍了病例报告和病理所见，并对文献报道的66例类似病例进行了分析。作者认为，鉴于存在类似于豚鼠唾液腺疾病的包涵体，该疾病一定是由病毒引起的。提示本病是胎儿死亡的常见原因。[包涵体可能存在于许多非感染性疾病中，现在不被视为病毒存在的明确证据。这种疾病was.at曾经被认为是一种原生动物感染。D. J·鲍尔
Six fatal cases of cytomegalic inclusion disease in infants are described. The series comprised one stillbirth and 5 infants of ages up to 14 months. The inclusions were of the type found in the salivary gland of guineapigs, and in a considerable proportion of normal infants, but in the cases in question they were widely distributed throughout the body and occurred particularly in the lungs, liver and kidneys, and the lesions produced were sufficiently severe to be regarded as the cause of death. The cases were variously diagnosed as purpura, whooping cough, enteritis and bronchopneumonia, and the correct diagnosis was only madepost mortem. The case reports and pathological findings are given in detail, and an analysis is also given of 66 similar cases reported in the literature. The authors maintain that the disease must be due to a virus, in view of the presence of inclusion bodies which resemble those of salivary gland disease of guineapigs. It is suggested that the disease is a common cause of fetal death. [Inclusions may be present in a number of non-infective conditions, and are not now regarded as unequivocal evidence for the presence of a virus. This disease was.at one time actually considered to be a protozoal infection.]D. J. Bauer.