Long-term prognostic assessment of 185 newly diagnosed gliomas: Grade III glioma showed prognosis comparable to that of Grade II glioma.
Long-term prognostic assessment of 185 newly diagnosed gliomas: Grade III glioma showed prognosis comparable to that of Grade II glioma.
复制标题
对 185 例新诊断的胶质瘤的长期预后评估：III 级胶质瘤的预后与 II 级胶质瘤相当。
DOI：
10.1093/jjco/hyn099
复制
发表时间：
2008
影响因子：
2.4
通讯作者：
T. Hori
中科院分区：
文献类型：
--
作者：
C. Shinohara;Y. Muragaki;T. Maruyama;S. Shimizu;Masahiko Tanaka;Y. Kubota;Mitsuteru Oikawa;R. Nakamura;H. Iseki;O. Kubo;K. Takakura;T. Hori
目的
通过WHO Ⅱ、Ⅲ、Ⅳ级脑胶质瘤分级标准对新诊断脑胶质瘤患者的预后进行评价，以评估我院脑胶质瘤治疗效果的总体趋势。并对影响预后的因素进行统计学分析。
方法
2000年至2006年，共对185例新诊断的胶质瘤患者进行了手术治疗。主要终点是从手术之日起的总生存期。评估是否影响预后的因素包括性别、年龄、病变部位、术前Karnofsky体力状态（KPS）、切除范围和是否进行放射治疗等WHO分级。
结果
WHO分级对生存期有显著影响（P < 0.0001）。II级和III级患者的生存率无统计学差异（P = 0.174），而III级和IV级患者的生存率有统计学差异（P < 0.0001）。影响生存率及评分的因素为KPS评分（P < 0.0001）。KPS = 100、KPS 80-90的两个KPS组在同一KPS组WHO分级上的生存率比较也有显著性差异（分别为P = 0.0009和0.0143）。
结论
尽管KPS的分布不同，但III级胶质瘤患者的生存率与II级相当。另一方面，与II级或III级相比，IV级胶质瘤患者的生存率明显较差。
OBJECTIVE
We evaluated the prognoses of newly diagnosed gliomas through WHO Grades II, III and IV to assess the overall tendency of treatment results for glioma in our institute. Furthermore, statistical analysis was performed to determine factors influencing the prognosis.
METHODS
A total of 185 newly diagnosed glioma patients were operated on from 2000 to 2006. The primary endpoint was the overall survival from the date of surgery. The factors assessed as to whether they influenced the prognosis were the WHO grades of sex, age, location of the lesion, pre-operative Karnofsky Performance Status (KPS), extent of resection and whether or not radiation therapy was performed.
RESULTS
The WHO grades influenced the survival significantly (P < 0.0001). The Grades II and III showed no statistically significant difference in survival (P = 0.174), whereas Grades III and IV showed a significant difference (P < 0.0001). The factor influencing survival as well as the grades was the KPS (P < 0.0001). The comparison of survival over WHO grades in the same KPS group was performed for 2 KPS groups (KPS = 100, KPS 80-90), and these also showed significant differences (P = 0.0009 and 0.0143, respectively).
CONCLUSIONS
Despite the different distributions of the KPS, the Grade III glioma patients showed survival comparable to that of the Grade II. On the other hand, the Grade IV glioma patients showed significantly poorer survival compared with Grade II or III.