Efficacy of different types of treatment in FIGO stage IB2 cervical cancer in Korea: results of a multicenter retrospective Korean study (KGOG-1005)
Efficacy of different types of treatment in FIGO stage IB2 cervical cancer in Korea: results of a multicenter retrospective Korean study (KGOG-1005)
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DOI：
10.1111/j.1525-1438.2007.00803.x
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发表时间：
2007-01-01
影响因子：
4.8
通讯作者：
Kim, J. -H.
中科院分区：
文献类型：
--
作者：
Ryu, H. -S.;Kang, S. B.;Kim, J. -H.
本研究的目的是回顾过去10年来韩国的FIGO IB 2期宫颈癌，评价最常用和适当的管理策略，并评估新辅助化疗（NAC）的生存益处。这是对1995年至2005年727例FIGO IB 2期患者的回顾性病历审查。692例患者入组，患者死亡的所有日期均通过韩国国家统计局的“国家死亡统计登记处”进行双重检查。根据主要治疗方式，将管理策略分为五组。在过去10年中，韩国IB 2期宫颈癌最常用的主要治疗方式是根治性子宫切除术（RH）。其次是NAC，其次是放疗（RT）和/或筋膜外子宫切除术，同步放化疗（CCRT）和/或筋膜外子宫切除术，降序排列。手术组的结果最好，5年无病生存率为89%。然而，手术组、NAC组和CCRT组之间无统计学差异。在韩国过去10年中，对于FIGO IB 2期宫颈癌，RH和辅助RT或CCRT是最常用的治疗策略。作为主要治疗手段，RH、NAC和CCRT显示出相似的生存率。然而，在上述治疗策略中，RH表现出最好的存活率。
The purpose of this study is to review FIGO stage IB2 cervical cancers in Korea for the past 10 years, and evaluate the most frequently employed and appropriate management strategy, and also assess the survival benefits of neoadjuvant chemotherapy (NAC). This is a retrospective chart review of 727 FIGO stage IB2 patients from 1995 to 2005. Six hundred ninety-two patients were enrolled, and all dates on which the patients died were double checked through the "National Registry of Death Statistics" of the Korea National Statistical Office. Management strategies were divided into five groups according to the primary treatment modality. The most frequently employed primary treatment modality for stage IB2 cervical cancer in Korea during the past 10 years was radical hysterectomy (RH). The next was NAC, followed by radiotherapy (RT) and/or extrafascial hysterectomy, concurrent chemoradiotherapy (CCRT) and/or extrafascial hysterectomy, in descending order. The surgery group showed the best results, with an 89% 5-year disease-free survival rate. However, there was no statistical difference between the surgery, NAC, and CCRT groups. For FIGO stage IB2 cervical cancer during the past 10 years in Korea, RH and adjuvant RT or CCRT was the most frequently employed treatment strategy. As a primary modality, RH, NAC, and CCRT showed similar survival rates. However, RH demonstrated the best survival rate among the above treatment strategies.