Impaired trace eyeblink conditioning in bilateral, medial-temporal lobe amnesia
Impaired trace eyeblink conditioning in bilateral, medial-temporal lobe amnesia
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DOI：
10.1037/0735-7044.111.5.873
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发表时间：
1997-10-01
影响因子：
1.9
通讯作者：
Disterhoft, JF
中科院分区：
文献类型：
--
作者：
McGlincheyBerroth, R;Carrillo, MC;Disterhoft, JF
在双侧内侧-颞叶健忘症患者和之前表现出相同延迟眨眼条件作用的匹配对照组参与者中，对示踪眨眼经典条件作用进行了评估(J.D.E.Gabrieli等，1995)。在相隔至少2周的连续试验中，静音跟踪间隔变化的持续时间为500、750或1000毫秒；每次试验后进行消退试验。健忘症患者在所有追踪间隔中产生的条件性反应(CRS)明显少于对照组参与者。随着追踪间隔的延长，两组都产生了更少的CRS。因此，人类的颞叶记忆系统在跟踪而不是延迟的经典眨眼条件反射中对正常习得做出了重要贡献。
Trace eyeblink classical conditioning was assessed in patients with bilateral medial-temporal amnesia and matched control participants who had previously shown equivalent delay eyeblink conditioning (J. D. E. Gabrieli et al., 1995). The silent trace interval varied for durations of 500, 750, or 1,000 ms in successive sessions separated by at least 2 weeks; extinction trials followed each session. Patients with amnesia produced significantly fewer conditioned responses (CRs) than did control participants at all trace intervals. Both groups produced fewer CRs as the trace interval lengthened. Thus, the temporal lobe memory system in humans makes an essential contribution to normal acquisition in trace, but not delay, classical eyeblink conditioning.