Molecular control of local translation in axon development and maintenance
Molecular control of local translation in axon development and maintenance
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DOI：
10.1016/j.conb.2018.02.025
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发表时间：
2018-08-01
影响因子：
5.7
通讯作者：
Holt, Christine E.
中科院分区：
文献类型：
--
作者：
Cioni, Jean-Michel;Koppers, Max;Holt, Christine E.
轴突的尖端通常远离合成大多数蛋白质的细胞体。最近的研究表明，轴突 mRNA 运输和局部翻译是关键的调节机制，使这些遥远的细胞前哨能够快速响应外在因素并维持轴突稳态。在这里，我们回顾了最近的证据，这些证据表明局部蛋白质合成通过调节囊泡运输、细胞骨架重塑和线粒体完整性等多种细胞过程，在控制轴突形状、突触发生和轴突存活方面发挥着越来越广泛的作用。我们进一步强调了当前关于协调轴突中功能性连接 mRNA 的定位和翻译的调节机制的研究。
The tips of axons are often far away from the cell soma where most proteins are synthesized. Recent work has revealed that axonal mRNA transport and localised translation are key regulatory mechanisms that allow these distant outposts of the cell to respond rapidly to extrinsic factors and maintain axonal homeostasis. Here, we review recent evidence pointing to an increasingly broad role for local protein synthesis in controlling axon shape, synaptogenesis and axon survival by regulating diverse cellular processes such as vesicle trafficking, cytoskeletal remodelling and mitochondrial integrity. We further highlight current research on the regulatory mechanisms that coordinate the localization and translation of functionally linked mRNAs in axons.