ENVIRONMENTAL ANTECEDENTS OF YOUNG-ONSET PARKINSONS-DISEASE
ENVIRONMENTAL ANTECEDENTS OF YOUNG-ONSET PARKINSONS-DISEASE
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DOI：
10.1212/wnl.43.6.1150
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发表时间：
1993-06-01
期刊：
影响因子：
9.9
通讯作者：
NUTT, JG
中科院分区：
文献类型：
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作者：
BUTTERFIELD, PG;VALANIS, BG;NUTT, JG
我们进行了一项对帕金森病（YOPD）的探索性研究，以检查与疾病风险相关的职业和环境因素。这项病例对照研究包括63名YOPD患者（50岁或之前诊断）;对照组（n = 68）被诊断患有类风湿性关节炎。计算粗比值比（OR），以确定logistic回归分析的暴露变量。在控制了种族、教育程度、性别、年龄、诊断年龄和帕金森病（PD）家族史等变量后，PD与杀虫剂暴露呈正相关（OR = 5.75，p < 0.001），过去居住在熏蒸房屋中（OR = 5.25，p = 0.046），除草剂暴露（OR = 3.22，p = 0.033），诊断时居住在农村（OR = 2.72，p = 0.027），诊断前10年吃坚果和种子（OR = 1.49，p = 0. 02 1）。PD与5年时吸烟呈负相关（OR = 0.50，p = 0.027），10年（OR = 0.43，p = 0.012）和15岁（OR = 0.37，p = 0.005）、农场居住（OR = 0.38，p = 0.018）和暴露于二甲基亚砜（OR = 0.10，p < 0.001）。这些研究结果是一致的假设联系PD暴露于农药制剂。
We conducted an exploratory study of young-onset Parkinson's disease (YOPD) to examine occupational and environmental factors associated with disease risk. This case-control study included 63 YOPD patients (diagnosis on or before age 50); controls (n = 68) were diagnosed with rheumatoid arthritis. Crude odds ratios (ORs) were computed to identify exposure variables for logistic regression analyses. After controlling for the variables of race, educational level, sex, age, age at diagnosis, and family history of Parkinson's disease (PD), PD was positively associated with insecticide exposure (OR = 5.75, p < 0.001), past residency in a fumigated house (OR = 5.25, p = 0.046), herbicide exposure (OR = 3.22, p = 0.033), rural residency at time of diagnosis (OR = 2.72, p = 0.027), and nuts and seed eating 10 years before diagnosis (OR = 1.49, p = 0. 02 1). PD was inversely associated with cigarette smoking at 5 years (OR = 0.50, p = 0.027), 10 years (OR = 0.43, p = 0.012), and 15 years (OR = 0.37, p = 0.005) before diagnosis, farm residency (OR = 0.38, p = 0.018), and exposure to dimethyl sulfoxide (OR = 0.10, p < 0.001). These findings are consistent with hypotheses linking PD to exposure to pesticide agents.