Protein NMR extends into new fields of structural biology
Protein NMR extends into new fields of structural biology
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DOI：
10.1016/s1367-5931(97)80074-9
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发表时间：
1997-10-01
影响因子：
7.8
通讯作者：
Cooke, RM
中科院分区：
文献类型：
--
作者：
Cooke, RM
蛋白质核磁共振的进展为理解大分子结构和相互作用打开了新的大门。同位素标记方法已经扩展了结构测定的尺寸限制，蛋白质-配体相互作用的映射现在被广泛使用，并导致了一种新的药物发现方法，可以跟踪蛋白质折叠过程的途径，并可以确定膜分子的结构。
Advances in protein NMR have opened new doors for the understanding of macromolecular structure and interactions. Isotope-labelling approaches have extended the size limit for structure determination, the mapping of protein-ligand interactions is now widely used and has led to a new drug discovery approach, pathways of protein folding processes can be followed, and the structures of molecules from membranes can be determined.