SPECIFIC UPTAKE OF SEROTONIN BY MURINE MACROPHAGES
SPECIFIC UPTAKE OF SEROTONIN BY MURINE MACROPHAGES
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DOI：
10.1016/0024-3205(88)90443-2
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发表时间：
1988-01-01
期刊：
影响因子：
6.1
通讯作者：
ROSZMAN, TL
中科院分区：
文献类型：
--
作者：
JACKSON, JC;WALKER, RF;ROSZMAN, TL
鉴于已报道的单胺类神经递质5-羟色胺(5-羟色胺)的免疫调节特性，本研究旨在评估5-羟色胺是否与免疫活性细胞特异性相关。虽然小鼠脾细胞似乎缺乏5-羟色胺的高亲和力结合部位，但它们确实具有与血小板相似的亲和力(Km=40 nm)的特异性、活性的5-羟色胺摄取系统。这种摄取系统似乎仅限于巨噬细胞。此外，巨噬细胞将5-羟色胺迅速代谢为5-羟基吲哚乙酸代谢物。因此，巨噬细胞对5-羟色胺的特异性摄取可能是这种胺能够调节免疫功能的一个重要机制。
In view of the reported immunomodulatory properties of the monoaminergic neurotransmitter, serotonin (5HT), this study aimed to assess whether 5HT specifically associates with immunocompetent cells. Although murines splenocytes appear to lack high-affinity membrane binding sites for 5HT, they do possess a specific, active, 5HT uptake system similar in affinity (Km = 40nM) to that described in platelets. This uptake system appears to be confined to macrophages. Further, macrophages rapidly metabolize 5HT to its 5-hydroxyindole acetic acid metabolite. Specific uptake of serotonin by macrophages may thus constitute an important mechanism whereby this amine is able to regulate immune function.