Telomere length, pre-eclampsia, and gestational diabetes.
Telomere length, pre-eclampsia, and gestational diabetes.
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DOI：
10.1186/1756-0500-3-113
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发表时间：
2010-04-23
影响因子：
1.8
通讯作者：
Risques RA
中科院分区：
文献类型：
--
作者：
Harville EW;Williams MA;Qiu CF;Mejia J;Risques RA
端粒长度是细胞累积损伤的标志，与心血管疾病、高血压和糖尿病有关。端粒长度与先兆子痫和妊娠糖尿病（GDM）的关联是在一个巢式病例对照研究中进行的。定量pcr法测定循环白细胞端粒长度。比较病例和对照组的平均端粒长度和中位数长度，并使用逻辑回归将结果建模为端粒长度的函数，并控制潜在混杂因素的影响。子痫前期患者端粒平均长度为0.77 (SD 0.14)， GDM患者端粒平均长度为0.73 (SD 0.10)，对照组端粒平均长度为0.74 （SD 0.14）。子痫前期最高胎率与最低胎率的校正比值比为0.92(0.15-5.46)，妊娠期糖尿病为0.65（0.13-3.34）。需要进一步的研究来确定端粒长度是否与这些妊娠并发症有关。
Telomere length is a marker of cumulative damage to the cell, and has been associated with cardiovascular disease, hypertension, and diabetes. The association of telomere length with pre-eclampsia and gestational diabetes mellitus (GDM) was examined in a nested case-control study. Circulating leukocyte telomere length was measured by Quantitative-PCR. Mean and median telomere length among cases and controls was compared, and logistic regression was used to model the outcomes as a function of tertile telomere length, with control for effects of potential confounders. Mean telomere length in pre-eclampsia cases was 0.77 (SD 0.14), in GDM cases was 0.73 (SD 0.10), and in controls was 0.74 (SD 0.14). The adjusted odds ratio comparing the highest tertile to the lowest for pre-eclampsia was 0.92 (0.15-5.46), and for gestational diabetes was 0.65 (0.13-3.34). Further study is necessary to determine if telomere length is associated with these pregnancy complications.