3β-p-hydroxybenzoyldehydrotumulosic acid from Poria cocos, and its anti-inflammatory effect
3β-p-hydroxybenzoyldehydrotumulosic acid from Poria cocos, and its anti-inflammatory effect
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DOI：
10.1016/s0031-9422(97)01063-7
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发表时间：
1998-08-01
期刊：
影响因子：
3.8
通讯作者：
Takido, M
中科院分区：
文献类型：
--
作者：
Yasukawa, K;Kaminaga, T;Takido, M
本文报道了一种从茯苓中分离得到的新三萜衍生物，经光谱和化学方法鉴定其结构为3 β-对羟基苯甲酰基脱氢土莫酸。3 β-对羟基苯甲酰基脱氢土莫酸对12-O-十四酰基佛波醇-13-乙酸酯（TPA）和花生四烯酸（AA）诱导的小鼠耳部炎症具有显著的抑制活性。对TPA和AA诱导的炎症，3 β-对羟基苯甲酰基脱氢tumulosic酸的50%抑制剂量分别为0.27和1.25 mg/耳。(C)1998爱思唯尔科技有限公司版权所有。
The structure of a new triterpene derivative isolated from Poria cocos was determined to be 3 beta-p-hydroxybenzoyldehydrotumulosic acid by spectral and chemical methods. 3 beta-p-hydroxybenzoyldehydrotumulosic acid showed marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)and arachidonic acid (AA)-induced ear inflammation in mice. The 50% inhibitory doses of 3 beta-p-hydroxybenzoyldehydrotumulosic acid were 0.27 and 1.25 mg per ear on TPA- and AA-induced inflammation, respectively. (C) 1998 Elsevier Science Ltd. All rights reserved.