No association between plasma hepcidin levels and restless legs syndrome-results from the Danish Blood Donor Study
No association between plasma hepcidin levels and restless legs syndrome-results from the Danish Blood Donor Study
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DOI：
10.1016/j.sleep.2021.10.008
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发表时间：
2021-11-01
期刊：
影响因子：
4.8
通讯作者：
Ullum, Henrik
中科院分区：
文献类型：
--
作者：
Dowsett, Joseph;Didriksen, Maria;Ullum, Henrik
背景：不宁腿综合征（RLS）是一种发生在傍晚和夜间的神经感觉运动障碍，因此经常影响患者的睡眠质量。虽然铁调节失调被认为是一种可能的途径，但RLS的病因尚不完全清楚。RLS与铁调节蛋白hepcidin之间的关系尚未在大型队列中进行研究。我们的目的是评估血浆hepcidin变异与RLS之间的关联是否存在于一大群健康个体中。方法：对来自丹麦献血者研究的9708名丹麦献血者的血浆hepcidin水平进行测量，这些献血者均正确完成了用于RLS评估的剑桥-霍普金斯RLS问卷。结果：本组共466名献血者被确定为RLS患者（4.8%）。RLS患者中女性比例（56.7% vs 46.7%, P < 0.001）明显高于对照组，且年龄（中位年龄[IQR] 40.6岁vs 38.0岁，P = 0.010）明显大于对照组。RLS患者也更常吸烟（P = 0.004）。在体重指数（BMI）、饮酒量、捐献时间和捐献史方面，病例与对照组无显著差异。RLS患者与对照组血浆hepcidin水平无差异（RLS患者的中位浓度[IQR]: 10.5 ng/ml[6.3-16.4]，对照组为10.5 ng/ml[6.0-16.5]）。采用logistic回归模型，在调整年龄、性别、饮酒、吸烟、捐献时间和捐献史等因素后，我们发现hepcidin水平与RLS无关（每增加1 ng/ml hepcidin， OR = 1.00 [0.99-1.02]; P = 0.429）。结论：我们对丹麦献血者的研究没有发现RLS和血浆hepcidin水平之间的关联。我们的研究结果表明，血浆hepcidin作为RLS的潜在诊断生物标志物的作用是不够的。(c) 2021提交人。这是一篇基于CC by许可（http://creativecommons.org/licenses/by/4.0/）的开放获取文章。
Background: Restless Legs Syndrome (RLS) is a neurological sensorimotor disorder that occurs in the evening and night, thereby often impacting quality of sleep in sufferers. The aetiology of RLS is not completely understood although iron dysregulation has been suggested as a likely pathway. The relationship between RLS and the iron regulatory protein hepcidin has not been studied in large cohorts. We aimed to assess whether an association between plasma hepcidin variation and RLS exists in a large cohort of healthy individuals. Methods: Plasma hepcidin levels were measured in 9708 Danish blood donors from the Danish Blood Donor Study all of whom correctly completed the validated Cambridge-Hopkins RLS-questionnaire for RLS assessment. Results: A total of 466 blood donors were determined as current RLS cases in the sample (4.8%). RLS cases had a significantly higher proportion of females (56.7% vs 46.7%; P < 0.001) and were older (median age [IQR] 40.6 years vs 38.0 years; P = 0.010) than controls. RLS cases were also more frequent smokers (P = 0.004). No significant differences were found in body mass index (BMI), alcohol consumption, time of donation and donation history between cases and controls. No difference in plasma hepcidin levels was observed between RLS cases and controls (median concentration [IQR]: 10.5 ng/ml [6.3-16.4] in RLS cases vs 10.5 ng/ml [6.0-16.5] in controls). Using a logistic regression model, we found that hepcidin levels were not associated with RLS after adjusting for age, sex, alcohol consumption, smoking status, donation time and donation history (OR = 1.00 [0.99-1.02] per 1 ng/ml increase of hepcidin; P = 0.429). Conclusion: Our study in Danish blood donors did not find an association between RLS and plasma hepcidin levels. Our findings suggest that plasma hepcidin's role as a potential diagnostic biomarker of RLS is inadequate. (c) 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).