STRIATAL HYPOMETABOLISM DISTINGUISHES STRIATONIGRAL DEGENERATION FROM PARKINSONS-DISEASE
STRIATAL HYPOMETABOLISM DISTINGUISHES STRIATONIGRAL DEGENERATION FROM PARKINSONS-DISEASE
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DOI：
10.1002/ana.410330517
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发表时间：
1993-05-01
影响因子：
11.2
通讯作者：
FAHN, S
中科院分区：
文献类型：
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作者：
EIDELBERG, D;TAKIKAWA, S;FAHN, S
使用f -18氟脱氧葡萄糖和正电子发射断层扫描对10例临床可能出现纹状体变性的患者（2男8女，平均年龄61.8 +/- 6.9岁，平均病程4.7 +/- 2.2年，平均Hoehn和Yahr评分3.5 +/- 0.8）进行区域和全球葡萄糖代谢率的估计。将这些患者的脑糖代谢测量值与10名年龄匹配的正常志愿者、10名疾病严重程度匹配的帕金森病（PD）患者和10名疾病持续时间匹配的帕金森病患者的脑糖代谢测量值进行比较。与正常和PD对照组相比，尾状核（p < 0.03）和壳核（p < 0.003）的正常化糖代谢显著降低，并将纹状体变性患者与对照组区分开来（p < 0.002）。纹状核变性患者的壳核低代谢与运动功能障碍的定量评分显著相关（p < 0.02）。这些结果表明，定量的f -18-氟脱氧葡萄糖正电子发射断层扫描技术可能有助于支持生活中纹状体变性的诊断，并客观评估疾病的严重程度和潜在的治疗干预措施。
Regional and global metabolic rates for glucose were estimated using F-18-fluorodeoxyglucose and positron emission tomography in 10 patients with a clinical likelihood of striatonigral degeneration (2 men and 8 women; mean age, 61.8 +/- 6.9 years; mean disease duration, 4.7 +/- 2.2 years; mean Hoehn and Yahr score, 3.5 +/- 0.8). Measures of brain glucose metabolism in these patients were compared with those for 10 age-matched normal volunteers, 10 disease severity-matched patients with Parkinson's disease (PD), and 10 disease duration-matched patients with PD. Normalized glucose metabolism was significantly reduced in the caudate (p < 0.03) and putamen (p < 0.003) as compared with that in normal and PD control subjects, and discriminated patients with striatonigral degeneration from control subjects (p < 0.002). Putamenal hypometabolism in patients with striatonigral degeneration correlated significantly with quantitative ratings of motor disability (p < 0.02). These results suggest that quantitative F-18-fluorodeoxyglucose positron emission tomography techniques may be useful in supporting a diagnosis of striatonigral degeneration in life, and in objectively assessing disease severity and potential therapeutic interventions.