Chronic zinc toxicity in an infant who received zinc therapy for atopic dermatitis
Chronic zinc toxicity in an infant who received zinc therapy for atopic dermatitis
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DOI：
10.1080/08035250510027354
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发表时间：
2005-09-01
期刊：
影响因子：
3.8
通讯作者：
Togari, H
中科院分区：
文献类型：
--
作者：
Sugiura, T;Goto, K;Togari, H
在日本和许多其他工业化国家，锌可作为营养补充剂，用于美容目的和治疗特应性皮炎。然而，与其使用相关的潜在风险尚未得到充分认识。由于铜和锌之间存在相互关系，过量的锌可产生低铜血症，这可引起贫血和中性粒细胞减少症。我们报告一个男婴谁提出了贫血和中性粒细胞减少症，并表现出发育迟缓的迹象后，食物过敏和进食困难的饮食限制和锌治疗特应性皮炎的治疗剂量为9倍的每日膳食津贴，他的年龄组。停锌1个月后，铜和铜蓝蛋白浓度增加，血细胞计数改善，活动增加，但语言发育仍然有限。由于发展改善后撤回锌，我们不能排除发展迟缓和高锌血症和/或hypocupraemia.Conclusion：必须谨慎行使锌给儿童在他们的神经发育。
In Japan and many other industrialized countries, zinc is readily available as a nutritional supplement, for cosmetic purposes and for the treatment of atopic dermatitis. The potential risks associated with its use are not, however, fully recognized. As a reciprocal relationship exists between copper and zinc, excessive zinc can produce hypocupraemia, which can cause anaemia and neutropenia. We report on a male infant who presented with anaemia and neutropenia and showed signs of developmental delay after dietary restriction for food allergy and eating difficulties and zinc therapy administered for the treatment of atopic dermatitis at a dose nine times the daily dietary allowance for his age group. After 1 mo of zinc withdrawal, copper and ceruloplasmin concentrations had increased, and the blood cell count had improved, activity was increasing but verbal development remained limited. As development improved after withdrawal of zinc, we cannot rule out a relation between developmental delay and hyperzincaemia and/or hypocupraemia.Conclusion: Caution must be exercised in administering zinc to children during their neurological development.