Glycan complexity dictates microbial resource allocation in the large intestine.
Glycan complexity dictates microbial resource allocation in the large intestine.
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DOI：
10.1038/ncomms8481
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发表时间：
2015-06-26
影响因子：
16.6
通讯作者：
Bolam DN
中科院分区：
文献类型：
--
作者：
Rogowski A;Briggs JA;Mortimer JC;Tryfona T;Terrapon N;Lowe EC;Baslé A;Morland C;Day AM;Zheng H;Rogers TE;Thompson P;Hawkins AR;Yadav MP;Henrissat B;Martens EC;Dupree P;Gilbert HJ;Bolam DN
人类肠道微生物群的结构主要通过复杂膳食碳水化合物的降解来控制，但碳水化合物分解产物在微生物群成员之间共享的程度尚不清楚。我们在这里展示，使用木聚糖作为模型，通过微生物群的关键成员（如卵形拟杆菌）共享复杂碳水化合物的分解产物取决于目标聚糖的复杂性。由B表达的广泛木聚糖降解装置的表征。ovatus揭示了人肠道微生物群对多糖的分解比以前提出的模型明显更复杂，以前的模型是基于含有有限单糖侧链的木聚糖的解构。我们的报告提出了一种高度复杂和动态的木聚糖降解装置，该装置经过微调以识别呈现给人类肠道微生物群的多糖的不同形式。 人类肠道微生物群帮助我们降解复杂的膳食碳水化合物，如木聚糖，反过来，碳水化合物分解产物控制微生物群的结构。在这里，作者描述了肠道微生物群的关键成员卵形拟杆菌的木聚糖降解装置。
The structure of the human gut microbiota is controlled primarily through the degradation of complex dietary carbohydrates, but the extent to which carbohydrate breakdown products are shared between members of the microbiota is unclear. We show here, using xylan as a model, that sharing the breakdown products of complex carbohydrates by key members of the microbiota, such as Bacteroides ovatus, is dependent on the complexity of the target glycan. Characterization of the extensive xylan degrading apparatus expressed by B. ovatus reveals that the breakdown of the polysaccharide by the human gut microbiota is significantly more complex than previous models suggested, which were based on the deconstruction of xylans containing limited monosaccharide side chains. Our report presents a highly complex and dynamic xylan degrading apparatus that is fine-tuned to recognize the different forms of the polysaccharide presented to the human gut microbiota. The human gut microbiota helps us to degrade complex dietary carbohydrates such as xylan and, in turn, the carbohydrate breakdown products control the structure of the microbiota. Here the authors characterize the xylan-degrading apparatus of a key member of the gut microbiota, Bacteroides ovatus.
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影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
5.8
作者：
Joosten, Robbie P.;Joosten, Krista;Perrakis, Anastassis
通讯作者：
Perrakis, Anastassis
影响因子：
4.1
作者：
Beylot, MH;McKie, VA;Gilbert, HJ
通讯作者：
Gilbert, HJ
影响因子：
3.4
作者：
Aspeborg H;Coutinho PM;Wang Y;Brumer H 3rd;Henrissat B
通讯作者：
Henrissat B
DOI：
10.1107/s0907444909042073
发表时间：
2010-01
期刊：
Acta crystallographica. Section D, Biological crystallography
影响因子：
--
作者：
Chen VB;Arendall WB 3rd;Headd JJ;Keedy DA;Immormino RM;Kapral GJ;Murray LW;Richardson JS;Richardson DC
通讯作者：
Richardson DC