HAb18G/CD147 is involved in TGF-β-induced epithelial-mesenchymal transition and hepatocellular carcinoma invasion
HAb18G/CD147 is involved in TGF-β-induced epithelial-mesenchymal transition and hepatocellular carcinoma invasion
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DOI：
10.1002/cbin.10341
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发表时间：
2015-01-01
影响因子：
3.9
通讯作者：
Bian, Huijie
中科院分区：
文献类型：
--
作者：
Ru, Ning-Yu;Wu, Jiao;Bian, Huijie
转化生长因子β（transforming growth factor beta，TGF-β）诱导的上皮-间质转化（Epithelial-mesenchymal transition，EMT）参与了肝癌的发生和转移。HAb 18 G/CD 147是免疫球蛋白家族的成员，在肿瘤的侵袭和转移中起重要作用。HAb 18 G/CD 147通过TGF-β信号促进肝细胞EMT，并受Slug的转录调控。我们研究了HAb 18 G/CD 147在TGF-β诱导的EMT在HCC侵袭中的作用。用两种人肝癌细胞系SMMC-7721和HepG 2研究HAb 18 G/CD 147在EMT中的作用。高剂量TGF-1诱导SMMC-7721（5 ng/mL）和HepG 2（10 ng/mL）细胞HAb 18 G/CD 147表达上调（P
Epithelial-mesenchymal transition (EMT) induced by the transforming growth factor beta (TGF-) is involved in hepatocarcinogenesis and hepatocellular carcinoma (HCC) metastasis. HAb18G/CD147, a member of the immunoglobulin family, plays an important role in tumor invasion and metastasis. HAb18G/CD147 promotes EMT of hepatocytes through TGF- signaling and is transcriptionally regulated by Slug. We investigated the role of HAb18G/CD147 in TGF--induced EMT in HCC invasion. Two human HCC cell lines, SMMC-7721 and HepG2, were used to determine the role of HAb18G/CD147 in EMT. Upregulation of HAb18G/CD147 induced by the high doses of TGF-1 in SMMC-7721 (5ng/mL) and HepG2 cells (10ng/mL) (P