Socioeconomic status is associated with striatal dopamine D2/D3 receptors in healthy volunteers but not in cocaine abusers.
Socioeconomic status is associated with striatal dopamine D2/D3 receptors in healthy volunteers but not in cocaine abusers.
复制标题
社会经济状况与健康志愿者中的纹状体多巴胺D2/D3受体有关，而在可卡因施虐者中则无关。
DOI：
10.1016/j.neulet.2016.01.056
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发表时间：
2016-03-23
影响因子：
2.5
通讯作者：
Volkow ND
中科院分区：
文献类型：
--
作者：
Wiers CE;Shokri-Kojori E;Cabrera E;Cunningham S;Wong C;Tomasi D;Wang GJ;Volkow ND
动物和人类的正电子发射断层扫描（PET）研究表明，社会地位与纹状体多巴胺D2/D3受体（D2/D3 R）的可用性有关。也就是说，在动物和人类中，较高的社会等级和评估社会地位的问卷调查中较高的分数分别与纹状体D2/D3 R的可用性呈正相关。此外，下属猴子容易受到可卡因自我管理，这表明社会等级的变化可以改变D2/D3 R的可用性和可卡因使用的脆弱性。在这里，我们调查了使用Hollingshead量表测量的社会经济地位（SES）是否与纹状体D2 D/3R可用性相关，使用[11 C]雷氯必利PET在38名可卡因滥用者和42名年龄和教育相匹配的健康对照者中进行。与对照组相比，可卡因滥用者在尾状核、壳核和腹侧纹状体中显示出较低的D2/D3 R可用性（所有p≤.001）。尽管受教育程度匹配，但可卡因滥用者的SES评分低于对照组（p<0.001）。仅在对照组中，SES评分与尾状核（r= 0.35，p= 0.024）和壳核（r= 0.39，p= 0.011）的D2/D3 R显著相关，但腹侧纹状体（p= 0.61）不相关;所有评分均经年龄校正。该研究证实，SES与健康人类志愿者的纹状体D2/D3 R可用性相关。然而，可卡因滥用者中D2/D3 R可用性的降低可能是由SES以外的因素驱动的，如慢性可卡因暴露。
Positron emission tomography (PET) studies in animals and humans have shown that social status is associated with striatal dopamine D2/D3 receptor (D2/D3R) availability. That is, higher social hierarchy and higher scores on questionnaires assessing social status correlated positively with striatal D2/D3R availability in animals and humans respectively. Furthermore, subordinate monkeys were vulnerable to cocaine self-administration, suggesting that alternations in social hierarchy can change D2/D3R availability and vulnerability to cocaine use. Here, we investigated whether socioeconomic status (SES) measured with the Hollingshead scale is associated with striatal D2D/3R availability using [11C]raclopride PET in 38 cocaine abusers and 42 healthy controls matched for age and education. Compared to controls, cocaine abusers showed lower D2/D3R availability in the caudate, putamen and ventral striatum (all p≤.001). Despite matching groups for education, SES scores were lower in cocaine abusers than controls (p<.001). In the control group only, SES scores significantly correlated with D2/D3R in caudate (r=.35, p=.024) and putamen (r=.39, p=.011) but not in ventral striatum (p=.61); all corrected for age. The study confirms that SES is associated with striatal D2/D3R availability in healthy human volunteers. However, reductions in D2/D3R availability in cocaine abusers may be driven by factors other than SES such as chronic cocaine exposure.