Voluntary exercise induces neurogenesis in the hypothalamus and ependymal lining of the third ventricle
Voluntary exercise induces neurogenesis in the hypothalamus and ependymal lining of the third ventricle
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DOI：
10.1007/s00429-015-0995-x
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发表时间：
2016-04-01
影响因子：
3.1
通讯作者：
Takahashi, Hideo
中科院分区：
文献类型：
--
作者：
Niwa, Atsuko;Nishibori, Masahiro;Takahashi, Hideo
在成人下丘脑和室管膜衬里的第三脑室，伸长细胞的功能，使连续的神经发生的多潜能祖细胞，这表明，伸长细胞可能能够介导恢复中风后的稳态功能。自愿轮运行已被证明可以改变神经化学和神经元功能，并增加啮齿动物的神经发生。在本研究中，我们发现，自愿运动提高了易卒中型自发性高血压大鼠（SHRSP/Kpo）的生存率和能量平衡。我们还研究了运动对下丘脑细胞的增殖和分化的影响，利用免疫反应的伸长细胞和神经标记。运动性SHRSP大鼠脑卒中前后与安静大鼠相比，延长细胞（可能是伸长细胞）的增殖增强。此外，细胞的增殖与第三脑室室管膜下细胞和脑脊液中成纤维细胞生长因子-2的诱导相关。运动SHRSP的新生细胞在卒中后部分分化为成熟神经元。我们的研究结果表明，自愿运动与下丘脑神经发生相关，导致中风后成人大脑内稳态功能的恢复。
In the adult hypothalamus and ependymal lining of the third ventricle, tanycytes function as multipotential progenitor cells that enable continuous neurogenesis, suggesting that tanycytes may be able to mediate the restoration of homeostatic function after stroke. Voluntary wheel running has been shown to alter neurochemistry and neuronal function and to increase neurogenesis in rodents. In the present study, we found that voluntary exercise improved the survival rate and energy balance of stroke-prone spontaneously hypertensive rats (SHRSP/Kpo). We also investigated the effect of exercise on the proliferation and differentiation of hypothalamic cells using immunoreactivity for tanycytes and neural markers. The proliferation of elongated cells, which may be the tanycytes, was enhanced in exercising SHRSP compared to sedentary rats before and after stroke. In addition, the proliferation of cells was correlated with the induction of fibroblast growth factor-2 in the subependymal cells of the third ventricle and in the cerebrospinal fluid. Some of the newborn cells of exercising SHRSP showed differentiation into mature neurons after stroke. Our results suggest that voluntary exercise correlates with hypothalamic neurogenesis, leading to recovery of homeostatic functions in the adult brain after stroke.