The role of inertial cavitation in acoustic droplet vaporization.
The role of inertial cavitation in acoustic droplet vaporization.
复制标题
DOI：
10.1109/tuffc.2009.1132
复制
发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
Fowlkes JB
中科院分区：
文献类型：
--
作者：
Fabiilli ML;Haworth KJ;Fakhri NH;Kripfgans OD;Carson PL;Fowlkes JB
使用超声将过热液滴乳剂汽化成气泡-称为声学液滴汽化（ADV）-在栓塞疗法和药物递送中具有潜在的治疗应用。ADV的治疗应用的优化可以通过了解ADV的物理机制来增强，目前还没有明确阐明。声空化是一种可能的机制。本文通过研究已知影响惯性空化阈值的参数，研究了ADV和惯性空化（IC）阈值（测量为峰值稀疏压力）之间的关系。这些参数包括体相流体性质，如气体饱和度、温度、粘度和表面张力;液滴参数，如润湿程度、表面活性剂类型和尺寸;以及声学性质，如脉冲重复频率和脉冲宽度。在所有情况下，ADV阈值发生在比IC阈值更低的稀疏压力下，表明相变发生在IC事件之前。示出的散装流体的粘度和温度直接和相反，分别影响这两个阈值。对于1至2.5 μ范围内的液滴，在阈值和直径之间观察到相反的趋势。基于实验参数的选择，有可能在有或没有IC的情况下实现ADV。
The vaporization of a superheated droplet emulsion into gas bubbles using ultrasound – termed acoustic droplet vaporization (ADV) – has potential therapeutic applications in embolotherapy and drug delivery. The optimization of ADV for therapeutic applications can be enhanced by understanding the physical mechanisms underlying ADV, which are currently not clearly elucidated. Acoustic cavitation is one possible mechanism. This paper investigates the relationship between the ADV and inertial cavitation (IC) thresholds (measured as peak rarefactional pressures) by studying parameters that are known to influence the IC threshold. These parameters include bulk fluid properties such as gas saturation, temperature, viscosity, and surface tension; droplet parameters such as degree of superheat, surfactant type, and size; and acoustic properties such as pulse repetition frequency and pulse width. In all cases the ADV threshold occurred at a lower rarefactional pressure than the IC threshold indicating that the phase-transition occurs before IC events. The viscosity and temperature of the bulk fluid are shown to influence both thresholds directly and inversely, respectively. An inverse trend is observed between threshold and diameter for droplets in the 1 to 2.5 μ range. Based on a choice of experimental parameters, it is possible to achieve ADV with or without IC.