VASECTOMY AND THE RISK OF PROSTATE-CANCER IN A COHORT OF MULTIPHASIC HEALTH-CHECKUP EXAMINEES - 2ND REPORT
VASECTOMY AND THE RISK OF PROSTATE-CANCER IN A COHORT OF MULTIPHASIC HEALTH-CHECKUP EXAMINEES - 2ND REPORT
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DOI：
10.1007/bf00053130
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发表时间：
1991-03-01
影响因子：
2.3
通讯作者：
CATTOLICA, EV
中科院分区：
文献类型：
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作者：
SIDNEY, S;QUESENBERRY, CP;CATTOLICA, EV
研究人员对 5,119 名自述有输精管结扎病史的男性进行了研究，这些男性是在 1977-82 年期间接受的多阶段健康检查中确定的，当时他们是北加州 Kaiser Permanente 医疗护理计划的成员。 为每个接受输精管切除术的男性确定了三个未接受输精管切除术的对照受试者，并在年龄、种族、婚姻状况以及检查日期和地点方面进行匹配。 前列腺癌发生后的平均随访时间为 6.8 年。 与输精管结扎术相关的前列腺癌相对风险为 1.0（95% 置信区间 = 0.7-1.6）；无论输精管结扎术与多阶段健康检查之间的间隔时间长短（小于10年、10-20年、大于20年）或输精管结扎术的年龄（小于40岁与大于40岁），相对风险约为1。 这些数据支持本研究组早期报告的研究结果，即输精管结扎术与随后的前列腺癌风险之间缺乏关联。
The relationship of vasectomy to prostate cancer was studied in 5,119 men with a self-reported history of vasectomy, identified at multiphasic health checkups undergone during 1977-82 while members of the Northern California Kaiser Permanente Medical Care Program. Three unvasectomized comparison subjects were identified for each vasectomized man, matched for age, race, marital status, and date and location of the examination. Follow-up for incident prostate cancer was conducted for a mean length of 6.8 years. The relative risk of prostate cancer associated with vasectomy was 1.0 (95% confidence interval = 0.7-1.6); the relative risk was approximately one, regardless of length of interval (less than 10 years, 10-20 years, more than 20 years) between vasectomy and multiphasic health checkup or the age at vasectomy (less than 40 years vs more than 40 years). These data support earlier findings reported in this study group of the lack of an association of vasectomy with subsequent risk of prostate cancer.