Complete genome sequence of bile-isolated Enterococcus avium strain 352
Complete genome sequence of bile-isolated Enterococcus avium strain 352
复制标题
胆汁分离的鸟肠球菌菌株 352 的完整基因组序列。
DOI：
10.1186/s13099-019-0294-9
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发表时间：
2019-04-24
期刊：
影响因子：
4.2
通讯作者：
Zuo, Xiuli
中科院分区：
文献类型：
--
作者：
Yu, Tao;Li, Lixiang;Zuo, Xiuli
鸟肠球菌（Enterococcus avium）是肠杆菌科（Enterobacteriaceae）的一种革兰氏阳性致病菌。E.禽流感可引起菌血症、腹膜炎和颅内化脓性感染。然而，其致病机制及其对特定生态位的适应性尚不清楚。从人胆汁中分离禽流感病毒株352，并进行全基因组测序。急诊禽流感病毒株352由一个环状的4，794，392bp的染色体和一个87，705bp的质粒组成。染色体GC含量为38.98%。在染色体和质粒中分别有4905和99个蛋白质编码序列。E.禽流感病毒株352含有许多据报道与胆汁适应相关的基因，包括bsh、sbcC、mutS、nifI、galU和hupB。与毒力相关的基因有esp、fss1、fss3、ecbA、bsh、lap、clpC、clpE和clpP。禽流感病毒株352，它有可能引起感染。此外，参与胆汁适应的基因可能有助于其在胆汁中生存的能力。进一步的比较基因组研究将有助于阐明大肠杆菌致病机制的进化。avium
BackgroundEnterococcus avium is a Gram-positive pathogenic bacterium belonging to the family Enterobacteriaceae. E. avium can cause bacteremia, peritonitis, and intracranial suppurative infection. However, the mechanism of its pathogenesis and its adaptation to a special niche is still unclear.ResultsIn this study, the E. avium strain 352 was isolated from human bile and whole genome sequencing was performed. The E. avium strain 352 consists of a circular 4,794,392bp chromosome as well as an 87,705bp plasmid. The GC content of the chromosome is 38.98%. There are 4905 and 99 protein coding sequences in the chromosome and the plasmid, respectively. The genome of the E. avium strain 352 contains number of genes reported to be associated with bile adaption, including bsh, sbcC, mutS, nifI, galU, and hupB. There are also several virulence-associated genes including esp, fss1, fss3, ecbA, bsh, lap, clpC, clpE, and clpP.ConclusionsThis study demonstrates the presence of various virulence factors of the E. avium strain 352, which has the potential to cause infections. Moreover, the genes involved in bile adaption might contribute to its ability to live in bile. Further comparative genomic studies would help to elucidate the evolution of pathogenesis of E. avium.