Characteristics of HPV prevalence among women in Liaoning province, China
Characteristics of HPV prevalence among women in Liaoning province, China
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辽宁省女性HPV感染特征
DOI：
10.1016/j.ijgo.2009.11.026
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发表时间：
2010-05-01
影响因子：
3.8
通讯作者：
Ruan, Qiang
中科院分区：
文献类型：
--
作者：
Sun, Zheng-Rong;Ji, Yao-Hua;Ruan, Qiang
目的：了解辽宁省中国地区女性人乳头瘤病毒感染情况。方法：采用芯片杂交法对4780例宫颈疾病患者和165例年龄匹配的对照组进行HPV基因分型。结果：宫颈炎组感染率为35.66%，ASCUS组为54.61%，CIN组为64.14%，宫颈原位癌组为83.76%，浸润性宫颈癌组为83.12%。最常见的HPV基因型是HPV-16，其次是HPV-58、HPV-52、HPV-33、HPV-53和HPV-31。4780例患者中单发感染1529例，多发感染731例。高危基因的单一感染与多种宫颈疾病相关。在399例多重感染患者中，HPV-16阳性。结论：辽宁省中国地区女性HPV型别感染率与其他人群不同。(C)2010年国际妇产科联合会。爱思唯尔爱尔兰有限公司出版。所有权利都不受欢迎。
Objectives: To investigate the prevalence rates of specific human papillomavirus (HPV) types infecting women in Liaoning Province, China. Methods: Specimens from 4780 patients with cervical disease and 165 age-matched controls were tested for HPV genotypes using a chip hybridization assay. Results: The infection rates were 35.66% for patients with cervicitis, 54.61% for those with ASCUS, 64.14% for those with CIN, 83.76% for those with cervical cancer in situ, and 83.12% for those with invasive cervical cancer. The most common HPV genotype was HPV-16, followed by HPV-58, HPV-52, HPV-33, HPV-53, and HPV-31. There were 1529 single and 731 multiple infections among the 4780 patients. Single infections with high-risk genotypes were associated with various cervical diseases. HPV-16 was present in 399 of the patients with multiple infections. Conclusion: Compared with prevalence rates for other populations, the rates of specific HPV types infecting women are different in Liaoning Province of China. (C) 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights resented.