Vital exhaustion in women with chest pain and no obstructive coronary artery disease: the iPOWER study
Vital exhaustion in women with chest pain and no obstructive coronary artery disease: the iPOWER study
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DOI：
10.1136/ebmental-2020-300175
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发表时间：
2021-05-01
影响因子：
5.2
通讯作者：
Prescott, Eva
中科院分区：
文献类型：
--
作者：
Bechsgaard, Daria Frestad;Gustafsson, Ida;Prescott, Eva
研究背景在有心肌缺血症状的女性中，超过一半的人没有阻塞性冠状动脉疾病（CAD），但他们面临着更高的心血管疾病死亡率和发病率。生命衰竭（VE）和抑郁症都与CAD患者的不良心血管预后有关。我们的目的是评估无阻塞性CAD的有症状女性是否比无症状女性更易发生生命衰竭。此外，我们调查的重叠之间的结构VE和depress.MethodsPrevalence和负担的VE进行了评估，在有症状的妇女没有阻塞性CAD（n=1.266）和无症状的妇女（n=2.390）。在有症状的妇女中，我们还评估了胸痛的特点和医院焦虑和抑郁问卷的症状。发现有症状和无症状妇女的VE评分中位数（IQR）分别为4（1-9）和2（0-5）（年龄校正，p
BackgroundMore than half of women with symptoms suggestive of myocardial ischaemia have no obstructive coronary artery disease (CAD), yet they face a higher risk of cardiovascular mortality and morbidity. Both vital exhaustion (VE) and depression have been linked to adverse cardiovascular prognosis in patients with CAD. We aimed to assess whether symptomatic women with no obstructive CAD are more vitally exhausted compared with asymptomatic women. Furthermore, we investigated the overlap between the constructs of VE and depression.MethodsPrevalence and burden of VE was assessed in symptomatic women with no obstructive CAD (n=1.266) and asymptomatic women (n=2.390). Among symptomatic women, we also assessed chest pain characteristics and symptoms of Hospital Anxiety and Depression Questionnaire.FindingsMedian (IQR) VE score was 4 (1-9) and 2 (0-5) in symptomatic and asymptomatic women, respectively (age adjusted, p