DNA methylation-based biomarkers of aging were slowed down in a two-year diet and physical activity intervention trial: the DAMA study.
DNA methylation-based biomarkers of aging were slowed down in a two-year diet and physical activity intervention trial: the DAMA study.
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DOI：
10.1111/acel.13439
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发表时间：
2021-10
期刊：
影响因子：
7.8
通讯作者：
Masala G
中科院分区：
文献类型：
--
作者：
Fiorito G;Caini S;Palli D;Bendinelli B;Saieva C;Ermini I;Valentini V;Assedi M;Rizzolo P;Ambrogetti D;Ottini L;Masala G
近年来，已经提出了几种健康衰老的生物标志物，包括基于DNA甲基化（DNAm）测量的表观遗传时钟，这些生物标志物在预测个体生物学年龄方面越来越准确。最近开发的“下一代时钟”DNAmGrimAge在预测寿命和许多与年龄相关的病理状况和疾病的发生方面优于“第一代时钟”。此外，随机表观遗传突变（SEMs）的总数，也称为表观遗传突变负荷（EML），已被提议作为健康衰老的基于DNA m的补充生物标志物。表观遗传的一个基本生物学特性，特别是DNA m修饰，是这种效应的潜在可逆性，这引起了人们对通过改变生活方式来减缓表观遗传衰老的可能性的质疑。在这里，我们调查了改善饮食习惯和增加体力活动是否对健康绝经后妇女的衰老生物标志物产生有利影响。研究样本由来自“饮食，体力活动和乳房X光检查”（DAMA）研究的219名女性组成：一项为期24个月的随机析因干预试验，在基线和试验结束时测量两次DNAm。参与饮食干预的女性的DNAmGrimAge时钟显着减慢，而增加体力活动导致关键癌症相关途径中的SEM显着减少。我们的研究提供了强有力的证据，证明生活方式的改变和DNA衰老生物标志物的减缓之间存在因果关系。这项随机试验阐明了生活方式与健康衰老相关的表观遗传机制之间的因果关系。在一项为期24个月的随机析因干预试验中，饮食和体力活动干预减缓了基于DNA甲基化的衰老生物标志物。
Several biomarkers of healthy aging have been proposed in recent years, including the epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting increasingly accurate in predicting the individual biological age. The recently developed “next‐generation clock” DNAmGrimAge outperforms “first‐generation clocks” in predicting longevity and the onset of many age‐related pathological conditions and diseases. Additionally, the total number of stochastic epigenetic mutations (SEMs), also known as the epigenetic mutation load (EML), has been proposed as a complementary DNAm‐based biomarker of healthy aging. A fundamental biological property of epigenetic, and in particular DNAm modifications, is the potential reversibility of the effect, raising questions about the possible slowdown of epigenetic aging by modifying one's lifestyle. Here, we investigated whether improved dietary habits and increased physical activity have favorable effects on aging biomarkers in healthy postmenopausal women. The study sample consists of 219 women from the “Diet, Physical Activity, and Mammography” (DAMA) study: a 24‐month randomized factorial intervention trial with DNAm measured twice, at baseline and the end of the trial. Women who participated in the dietary intervention had a significant slowing of the DNAmGrimAge clock, whereas increasing physical activity led to a significant reduction of SEMs in crucial cancer‐related pathways. Our study provides strong evidence of a causal association between lifestyle modification and slowing down of DNAm aging biomarkers. This randomized trial elucidates the causal relationship between lifestyle and healthy aging‐related epigenetic mechanisms. In a 24‐month randomized factorial intervention trial, dietary and physical activity interventions slowed down DNA methylation‐based biomarkers of aging.
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全基因组甲基化谱揭示了人类衰老速度的定量观点。
影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
DOI：
10.1093/bioinformatics/btv562
发表时间：
2016-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Gel B;Díez-Villanueva A;Serra E;Buschbeck M;Peinado MA;Malinverni R
通讯作者：
Malinverni R
影响因子：
--
作者：
Gentilini D;Scala S;Gaudenzi G;Garagnani P;Capri M;Cescon M;Grazi GL;Bacalini MG;Pisoni S;Dicitore A;Circelli L;Santagata S;Izzo F;Di Blasio AM;Persani L;Franceschi C;Vitale G
通讯作者：
Vitale G
影响因子：
13.6
作者：
Khan SS;Shah SJ;Klyachko E;Baldridge AS;Eren M;Place AT;Aviv A;Puterman E;Lloyd-Jones DM;Heiman M;Miyata T;Gupta S;Shapiro AD;Vaughan DE
通讯作者：
Vaughan DE
影响因子：
3.8
作者：
Gagliardi, Amedeo;Dugue, Pierre-Antoine;Fiorito, Giovanni
通讯作者：
Fiorito, Giovanni