THE RELATIONSHIP BETWEEN BENZODIAZEPINE RECEPTOR SENSITIVITY AND NEUROTICISM
THE RELATIONSHIP BETWEEN BENZODIAZEPINE RECEPTOR SENSITIVITY AND NEUROTICISM
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DOI：
10.1016/0887-6185(94)00026-7
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发表时间：
1995-01-01
影响因子：
10.3
通讯作者：
NUTT, D
中科院分区：
文献类型：
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作者：
GLUE, P;WILSON, S;NUTT, D
GABA（A）/苯二氮卓类受体敏感性的差异可能有助于神经质的人格特质进行了评估。我们比较了苯二氮卓类激动剂咪达唑仑对艾森克人格问卷神经质（N）量表得分低（小于或等于4）或高（大于或等于17）的两组志愿者的扫视眼球运动以及焦虑和镇静自我评分的影响。高N受试者的基线特质和状态焦虑评分更高。与低N受试者相比，咪达唑仑对高N受试者扫视准确性的影响显著较小，并且焦虑评分下降幅度更大。扫视数据表明，神经质人格特质的变化可能与苯二氮卓类受体敏感性的差异有关，这些也可能与非病理性焦虑和临床疾病有关。
The possibility that differences in GABA(A)/benzodiazepine receptor sensitivity might contribute to the personality trait of neuroticism was assessed. We compared the effects of the benzodiazepine agonist, midazolam, on saccadic eye movements and self-ratings of anxiety and sedation between two groups of volunteers with either low (less-than-or-equal-to 4) or high (greater-than-or-equal-to 17) scores on the Neuroticism (N) scale of the Eysenck Personality Questionnaire. Baseline trait and state anxiety ratings were greater in the high-N subjects. Midazolam had a significantly smaller effect on saccade accuracy in the high-N compared with the low-N subjects, and produced a greater fall in anxiety ratings. The saccade data suggest that variations in the personality trait of neuroticism may be related to differences in the sensitivity of benzodiazepine receptors, and that these may also be implicated in nonpathological anxiety as well as clinical disorders.