Maternal and Fetal Determinants of Neonatal Body Composition
Maternal and Fetal Determinants of Neonatal Body Composition
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DOI：
10.1159/000441298
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发表时间：
2015-01-01
影响因子：
3.2
通讯作者：
Hokken-Koelega, Anita C. S.
中科院分区：
文献类型：
--
作者：
Breij, Laura M.;Steegers-Theunissen, Regine P. M.;Hokken-Koelega, Anita C. S.
背景：生命早期的身体成分影响儿童期及以后肥胖的发展。因此，充分确定新生儿的身体成分非常重要。胎儿生长和母体因素可能会影响新生儿脂肪质量百分比 (FM%)，与出生体重无关。方法：在 194 名健康新生儿中，我们调查了通过排气体积描记法 (PEAPOD) 测量的新生儿身体成分，及其与估计胎儿体重 (EFW)、新生儿人体测量数据、母亲孕前体重指数 (BMI) 和母亲怀孕期间体重增加的关系。结果：即使出生体重相似，经性别和胎龄校正后，新生儿 FM% 也存在很大差异。新生儿 FM% 与妊娠 30 周和 36 周时的 EFW 以及妊娠 30 周和 36 周之间的体重追赶相关，但与 20 周时的 EFW 无关（分别为 p < 0.01、p < 0.01 和 p = 0.64）。新生儿 FM% 还与母亲孕前 BMI 相关（p < 0.01）。与母亲体重增加没有相关性。结论：我们的研究表明，足月新生儿的 FM% 存在较大差异。新生儿 FM% 与 30 至 36 周的 EFW、妊娠 30 至 36 周的体重追赶以及母亲的孕前 BMI 相关。 (C) 2015 S. Karger AG，巴塞尔
Background: Body composition in early life influences the development of obesity during childhood and beyond. It is, therefore, important to adequately determine neonatal body composition. Fetal growth and maternal factors might influence neonatal fat mass percentage (FM%), independent of birth weight. Methods: In 194 healthy neonates, we investigated neonatal body composition, measured by air-displacement plethysmography (PEAPOD), and its associations with estimated fetal weight (EFW), neonatal anthropometric data, maternal preconceptional body mass index (BMI) and maternal weight gain during pregnancy. Results: There was a large variation in neonatal FM%, even in case of a similar birth weight, corrected for gender and gestational age. Neonatal FM% was associated with EFW at 30 and 36 weeks of gestation and with catch-up in weight between 30 and 36 weeks of gestation, but not with EFW at 20 weeks (p < 0.01, p < 0.01 and p = 0.64, respectively). Neonatal FM% was also associated with preconceptional BMI of the mother (p < 0.01). There was no correlation with maternal weight gain. Conclusion: Our study shows that term neonates have a large variation in FM%. Neonatal FM% is associated with EFW at 30 and 36 weeks, catch-up in weight between 30 and 36 weeks of gestation and preconceptional BMI of the mother. (C) 2015 S. Karger AG, Basel