NONINVASIVE MEASUREMENT OF TISSUE MAGNESIUM AND CORRELATION WITH CARDIAC LEVELS
NONINVASIVE MEASUREMENT OF TISSUE MAGNESIUM AND CORRELATION WITH CARDIAC LEVELS
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DOI：
10.1161/01.cir.92.8.2190
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发表时间：
1995-10-15
期刊：
影响因子：
37.8
通讯作者：
SCHULMAN, SP
中科院分区：
文献类型：
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作者：
HAIGNEY, MCP;SILVER, B;SCHULMAN, SP
背景细胞内镁（[Mg]（i））在调节心肌代谢、收缩力以及维持跨肌膜和细胞内离子梯度中起重要作用。镁在临床环境中的作用的理解，但是，阻碍了缺乏细胞内组织镁水平的测定方法和结果，我们使用能量色散X射线分析测量[Mg]（i）在舌下上皮细胞和相关的水平与心房活检标本从相同的患者在心肺转流术。还测量了急性心肌梗死（AMI）患者静脉注射硫酸镁前后的水平，并与重症监护室（ICU）患者和健康人的水平进行了比较。在18例心脏手术患者中，舌下上皮细胞（平均值，32.1+/-0.3 mEq/L）和心房组织（平均值，32.1+/-0.3 mEq/L）[Mg]（i）之间存在强相关性（r= 0.68，P
Background Intracellular magnesium ([Mg](i)) plays an important role in the regulation of myocardial metabolism, contractility, and the maintenance of transsarcolemmal and intracellular ionic gradients. An understanding of the role of magnesium in the clinical setting, however, is hampered by the lack of an assay of intracellular tissue magnesium levels.Methods and Results We used energy-dispersive x-ray analysis to measure [Mg](i) in sublingual epithelial cells and to correlate the level with those in atrial biopsy specimens from the same patients during cardiopulmonary bypass. Levels were also measured in acute myocardial infarction (AMI) patients before and after intravenous magnesium sulfate administration and compared with those from intensive care unit (ICU) patients and healthy individuals. A strong correlation between sublingual epithelial cell (mean, 32.1+/-0.3 mEq/L) and atrial tissue (mean, 32.1+/-0.3 mEq/L) [Mg](i) was present in 18 cardiac surgery patients (r=.68, P