POPULATION STUDIES IN CAMEROON - HEMOGLOBIN-S, GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY AND FALCIPARUM-MALARIA
POPULATION STUDIES IN CAMEROON - HEMOGLOBIN-S, GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY AND FALCIPARUM-MALARIA
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DOI：
10.1159/000153138
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发表时间：
1980-01-01
期刊：
影响因子：
1.8
通讯作者：
NOCHE, LK
中科院分区：
文献类型：
--
作者：
BERNSTEIN, SC;BOWMAN, JE;NOCHE, LK
Examination of blood samples from 1183 individuals from Cameroon indicated that sickle cell trait frequencies and G6PD [glucose-6-phosphate dehydrogenase] deficiency frequencies were heterogeneous among villages and within geographic areas and ethnic groups. Mean parasite counts were significantly correlated with Hb AS frequencies for children 6 yr of age and under, although no correlation was found for mean parasite counts and G6PD deficiency frequencies. The mean age of sickle cell trait individuals was significantly greater than the mean age of Hb AA individuals. The mean age of G6PD-deficient males did not differ from the mean age of G6PD-normal males. Hb AA and Hb AS children did not differ significantly in mean positive parasite counts. Falciparum malaria [Plasmodium falciparum] appears to be a selective pressure keeping Hb S frequencies high; yet it may not be the major selective force maintaining the G6PD polymorphism.
