Modulated inflammation by injection of high-mobility group box 1 recovers post-infarction chronically failing heart
Modulated inflammation by injection of high-mobility group box 1 recovers post-infarction chronically failing heart
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DOI：
10.1161/circulationaha.107.757443
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发表时间：
2008-09-30
期刊：
影响因子：
37.8
通讯作者：
Suzuki, Ken
中科院分区：
文献类型：
--
作者：
Takahashi, Kunihiko;Fukushima, Satsuki;Suzuki, Ken
背景：炎症在心肌梗死后不良心室重构过程中起重要作用。高迁移率组框1 （HMGB1）是一种核蛋白，最近发现它在释放时也可以作为炎症调节剂。我们假设HMGB1注射可以优先调节局部心肌炎症，减轻心室重构，从而改善梗死后慢性心力衰竭的心脏性能。方法与结果：左冠状动脉结扎后3周，取HMGB1 （2.5 μ g）或PBS心内注射。注射后28天，HMGB1与PBS相比，左室射血分数显著提高(39.3 +/- 1.4 vs 33.3 +/- 1.8%
Background-Inflammation plays an important role in the progress of adverse ventricular remodeling after myocardial infarction. High-mobility group box 1 (HMGB1) is a nuclear protein, which has recently been uncovered to also act as a modifier of inflammation when released. We hypothesized that HMGB1 injection could preferentially modulate local myocardial inflammation, attenuate ventricular remodeling, and subsequently improve cardiac performance of postinfarction chronic heart failure.Methods and Results-Three weeks after left coronary artery ligation, HMGB1 (2.5 mu g) or PBS was intramyocardially injected into rat hearts. At 28 days after injection, left ventricular ejection fraction was significantly improved after HMGB1 injection compared to PBS (39.3 +/- 1.4 versus 33.3 +/- 1.8%; P