Emerging roles of PKM2 in cell metabolism and cancer progression.
Emerging roles of PKM2 in cell metabolism and cancer progression.
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DOI：
10.1016/j.tem.2012.06.010
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发表时间：
2012-11
影响因子：
10.9
通讯作者：
Semenza, Gregg L.
中科院分区：
文献类型：
--
作者：
Luo, Weibo;Semenza, Gregg L.
Increased conversion of glucose to lactate is a key feature of many cancer cells that promotes rapid growth. Pyruvate kinase M2 (PKM2) expression is increased and facilitates lactate production in cancer cells. Modulation of PKM2 catalytic activity also regulates synthesis of DNA and lipids required for cell proliferation and NADPH required for redox homeostasis. In addition to its role as a pyruvate kinase, PKM2 also functions as a protein kinase and as a transcriptional coactivator. These biochemical activities are controlled by allosteric regulators and post-translational modifications of PKM2 that include acetylation, oxidation, phosphorylation, prolyl hydroxylation, and sumoylation. Given its pleiotropic effects on cancer biology, PKM2 represents an attractive target for cancer therapy.
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DOI：
10.1126/science.1211485
发表时间：
2011-12-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Anastasiou D;Poulogiannis G;Asara JM;Boxer MB;Jiang JK;Shen M;Bellinger G;Sasaki AT;Locasale JW;Auld DS;Thomas CJ;Vander Heiden MG;Cantley LC
通讯作者：
Cantley LC
影响因子：
4.8
作者：
Discher, DJ;Bishopric, NH;Webster, KA
通讯作者：
Webster, KA
影响因子：
2.9
作者：
Friesen, RHE;Castellani, RJ;Braun, W
通讯作者：
Braun, W
影响因子：
5.3
作者：
Kim, JW;Zeller, KI;Dang, CV
通讯作者：
Dang, CV
影响因子：
4.8
作者：
Hoshino, Akemi;Hirst, John A.;Fujii, Hodaka
通讯作者：
Fujii, Hodaka