Meta-analysis of cognitive performance in drug-naive patients with schizophrenia
Meta-analysis of cognitive performance in drug-naive patients with schizophrenia
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DOI：
10.1016/j.schres.2014.06.034
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发表时间：
2014-09-01
影响因子：
4.5
通讯作者：
Farde, Lars
中科院分区：
文献类型：
--
作者：
Fatouros-Bergman, Helena;Cervenka, Simon;Farde, Lars
认知缺陷是精神分裂症的一个重要特征。然而，大多数临床研究是在接受抗精神病药物治疗的患者中进行的。因此，目前尚不清楚在没有药物治疗的情况下是否存在严重的认知障碍。这是首次对精神分裂症初治患者的认知结果进行荟萃分析。纳入了1992年至2013年发表的23项研究的认知数据，包括1106名患者和1385名对照。根据提高精神分裂症认知能力的测量和治疗研究（MATRICS），测试在很大程度上是在认知领域进行的。使用随机效应模型和异质性以及Egger的发表偏倚进行分析与STATA。总的来说，结果显示，患者在所有认知领域的表现都比健康对照组差，具有中等至大的效应量。言语记忆、处理速度和工作记忆是受损最严重的三个领域。结果模式与既往抗精神病药物治疗患者的荟萃分析结果一致。目前的荟萃分析证实，在没有抗精神病药物的情况下，在疾病的早期阶段存在显着的认知障碍。(C)2014作者由Elsevier B. V.发布。这是CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/3.0/）。
Cognitive deficits represent a significant characteristic of schizophrenia. However, a majority of the clinical studies have been conducted in antipsychotic drug treated patients. Thus, it remains unclear if significant cognitive impairments exist in the absence of medication. This is the first meta-analysis of cognitive findings in drug-na ve patients with schizophrenia. Cognitive data from 23 studies encompassing 1106 patients and 1385 controls published from 1992 to 2013 were included. Tests were to a large extent ordered in cognitive domains according to the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) battery. Analysis was performed with STATA using the random-effects model and heterogeneity as well as Egger's publication bias was assessed. Overall the results show that patients performed worse than healthy controls in all cognitive domains with medium to large effect sizes. Verbal memory, speed of processing and working memory were three of the domains with the greatest impairments. The pattern of results is in line with previous meta-analytic findings in antipsychotic treated patients. The present meta-analysis confirms the existence of significant cognitive impairments at the early stage of the illness in the absence of antipsychotic medication. (C) 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).