Surgical outcomes and survival of adrenocortical carcinoma between children and adults.
Surgical outcomes and survival of adrenocortical carcinoma between children and adults.
复制标题
DOI：
10.1016/j.amjsurg.2022.05.033
复制
发表时间：
2022-10
影响因子：
3
通讯作者：
Hayes, Andrea A.
中科院分区：
文献类型：
--
作者：
Akinkuotu, Adesola C.;Peace, Alyssa;Maduekwe, Ugwuji N.;Hayes, Andrea A.
Adrenocortical carcinoma (ACC) is associated with poor outcomes. We compared surgical outcomes between children and adult; and identified factors independently associated with survival. Using the National Cancer Database, children and adults with ACC who underwent surgery between 2004 and 2016 were identified. We compared outcomes and survival between groups. Cox regression analysis was performed to identify predictors of survival. Of 2553 patients, 2.8% were children. A higher proportion of children were Hispanic (19.1%vs.6.6%) and covered by government insurance (45.1%vs.35.8%) than adults. More pediatric patients received lymphadenectomy and chemotherapy than adults. Pediatric patients had better survival at 1 -(91.4%; 95%CI: 81.2%– 96.0% vs.79.6%; 95%CI: 77.9%–81.1%) and 5-years (60.6%; 95%CI:47.5%–71.3% vs.44.9%; 95%CI 42.7%−47.0) (p = 0.0016). Age≥18 (HR: 2.21(1.50–3.27)), metastatic disease at diagnosis (HR: 3.51(3.04–4.04)), and receipt of lymphadenectomy (HR: 1.30(1.14–1.48)) were independently associated with worse survival. Children with ACC had better survival than adults. Factors independently associated with worse survival included older age, metastatic disease, and receipt of lymph node surgery.
登录
查看更多内容
影响因子：
2.4
作者：
McAteer, Jarod P.;Huaco, Jorge A.;Gow, Kenneth W.
通讯作者：
Gow, Kenneth W.
影响因子：
4.2
作者：
Kerkhofs, T. M. A.;Ettaieb, M. H. T.;Haak, H. R.
通讯作者：
Haak, H. R.
影响因子：
2.4
作者：
Gulack, Brian C.;Rialon, Kristy L.;Tracy, Elisabeth T.
通讯作者：
Tracy, Elisabeth T.
影响因子：
5.8
作者：
Gharzai, Laila A.;Green, Michael D.;Jolly, Shruti
通讯作者：
Jolly, Shruti
影响因子：
1.7
作者：
Zekri, Wael;Hammad, Mahmoud;Alfaar, Ahmad S.
通讯作者：
Alfaar, Ahmad S.