Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation.
Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation.
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发表时间：
1997-08
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通讯作者：
Roger S Smith;Terry J. Smith;T. Blieden;R. Phipps
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作者：
Roger S Smith;Terry J. Smith;T. Blieden;R. Phipps
在这篇评论中，我们建议应将成纤维细胞视为哨兵细胞。这个概念是基于成纤维细胞的能力，既作为一个结构要素，并作为一个重要的免疫调节细胞。在某些组织中，这些能力可能归因于成纤维细胞的亚群，而不是一些一般的成纤维细胞群体。Xia等人以及其他人的开创性研究强调了探索成纤维细胞在疾病中发挥关键作用的重要性。新兴的概念，组织特异性成纤维细胞和成纤维细胞的异质性需要考虑在其生物合成能力的研究。特别重要的是最近的见解，NF κ B B/RelB家族的转录蛋白在成纤维细胞和造血细胞中具有明显不同的调节作用。因此，关于靶向分子如RelB的治疗策略，应谨慎行事，因为与成纤维细胞相比，它们的中断可能在巨噬细胞中具有非常不同的后果。例如，在巨噬细胞中抑制RelB可以很好地防止增强的趋化因子表达，而在成纤维细胞中，用于防止趋化因子表达的关键调控因子将丢失。总的来说，这可能导致炎症加剧，而不是减弱该过程。
In this commentary, we have suggested that the fibroblast should be considered a sentinel cell. This concept is based on the fibroblast's ability to function both as a structural element and as a vital immunoregulatory cell. In some tissues, these capabilities may be ascribable to subsets of fibroblasts, rather than to some of the general fibroblast populations. The pioneering research of Xia et al, as well as that of others, highlights the need to explore the importance of fibroblasts as playing critical roles in disease. Emerging concepts regarding tissue-specific fibroblasts and fibroblast heterogeneity need to be considered in studies of their biosynthetic capabilities. Of special importance is the recent insight that the NF kappa B/RelB family of transcription proteins have apparently different regulatory roles in fibroblasts and hematopoietic cells. Therefore, with regard to therapeutic strategies targeting molecules such as RelB, caution should be exercised as their interruption may have very different consequences in macrophages compared with fibroblasts. For example, inhibition of RelB in macrophages may well prevent enhanced chemokine expression, whereas in fibroblasts, a critical governor for preventing chemokine expression would be lost. Overall, this could lead to exacerbation of inflammation rather than to an attenuation of the process.