Changes of human B and B-1a peripheral blood lymphocytes with age
Changes of human B and B-1a peripheral blood lymphocytes with age
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DOI：
10.1080/10245330701255270
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发表时间：
2007-01-01
期刊：
影响因子：
1.9
通讯作者：
Ortolani, Riccardo
中科院分区：
文献类型：
--
作者：
Veneri, Dino;Franchini, Massimo;Ortolani, Riccardo
在维罗纳大学医院免疫科病理科收治的2057名连续受试者中，测定了CD 19+和CD 5/CD 19双阳性细胞，以评估衰老过程中人类总外周B-淋巴细胞和B- 1a（CD 5+）隔室的行为。我们发现，总B淋巴细胞的绝对数量在生命的第一年从基线条件增加约三倍，并逐渐减少，直到成年。从成年年龄开始检测到缓慢下降。在B-淋巴细胞的B- 1a亚群中也观察到类似的行为，尽管成年后的下降似乎更明显。考虑到可能的生理解释和/或疾病状态的影响。
In 2057 consecutive subjects admitted to the Department of Pathology, Section of Immunology of the Verona University Hospital, CD19+ and CD5/ CD19 double positive cells were determined to assess the behaviour of total peripheral B- lymphocytes and B- 1a ( CD5+) compartments in humans during aging. We show that the absolute number of total B lymphocytes increases about three- fold from the baseline conditions in the first year of life and progressively decreases until adult age. A slower decrease was detected from the adult age onwards. A similar behaviour has been observed within the B- 1a subset of B- lymphocytes, although the decrease after the adult age seems more pronounced. Possible physiological explanations and/ or implications for the disease states are taken into account.