THE SON OF SEVENLESS GENE-PRODUCT - A PUTATIVE ACTIVATOR OF RAS
THE SON OF SEVENLESS GENE-PRODUCT - A PUTATIVE ACTIVATOR OF RAS
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DOI：
10.1126/science.1736363
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发表时间：
1992-01-31
期刊：
影响因子：
56.9
通讯作者：
BANERJEE, U
中科院分区：
文献类型：
--
作者：
BONFINI, L;KARLOVICH, CA;BANERJEE, U
Sons of sevenless（Sos）基因在由sevenless和表皮生长因子受体酪氨酸激酶启动的信号通路中起作用。目前，Sos基因已被分离并测序。它的产物是一种1595个氨基酸的蛋白质，类似于酿酒酵母中的CDC 25蛋白，是一种激活Ras的鸟嘌呤核苷酸交换因子。这些结果意味着ras通路在果蝇神经元发育中的作用。
The Son of sevenless (Sos) gene functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases. The Sos gene has now been isolated and sequenced. Its product is a 1595 - amino acid protein similar to the CDC25 protein in Saccharomyces cerevisiae, a guanine nucleotide exchange factor that activates Ras. These results imply a role for the ras pathway in Drosophila neuronal development.