Reductive Cross-Coupling Reactions between Two Electrophiles
Reductive Cross-Coupling Reactions between Two Electrophiles
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DOI：
10.1002/chem.201402302
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发表时间：
2014-06-02
影响因子：
4.3
通讯作者：
Jacobi von Wangelin, Axel
中科院分区：
文献类型：
--
作者：
Knappke, Christiane E. I.;Grupe, Sabine;Jacobi von Wangelin, Axel
还原性交叉亲电偶联反应是近年来发展起来的一种多功能、可持续的选择性CC键合成方法。使用廉价且丰富的亲电试剂避免了有机金属试剂的预形成和处理。原位还原偶联在过渡金属催化剂（Ni、Co、Pd、Fe）和合适的金属还原剂（Mn、Zn、Mg）的存在下进行。这篇概念文章评估了最新的技术水平，总结了烷基，烯基，烯丙基和芳基试剂的各种组合的最新方案，并强调了关键的机理研究。
Reductive cross-electrophile coupling reactions have recently been developed to a versatile and sustainable synthetic tool for selective CC bond formation. The employment of cheap and abundant electrophiles avoids the pre-formation and handling of organometallic reagents. In situ reductive coupling is effected in the presence of a transition-metal catalyst (Ni, Co, Pd, Fe) and a suitable metallic reductant (Mn, Zn, Mg). This Concept article assesses the current state of the art and summarizes recent protocols with various combinations of alkyl, alkenyl, allyl, and aryl reagents and highlights key mechanistic studies.