Relationship between the anti‐HTLV‐1 antibody level, the number of abnormal lymphocytes and the viral‐genome dose in HTLV‐1‐infected individuals
Relationship between the anti‐HTLV‐1 antibody level, the number of abnormal lymphocytes and the viral‐genome dose in HTLV‐1‐infected individuals
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HTLV-1感染者抗HTLV-1抗体水平、异常淋巴细胞数量和病毒基因组剂量之间的关系
DOI：
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发表时间：
1993
影响因子：
6.4
通讯作者：
T. Kanda
中科院分区：
文献类型：
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作者：
O. Shinzato;H. Shiku;Y. Nagata;E. Nakayama;S. Kamihira;S. Ikeda;H. Kondo;T. Kanda
两种不同的疾病，成人T细胞白血病（ATL）和HTLV‐1相关的脊髓病/热带痉挛性麻痹（HAM/TSP），在少量HTLV‐1携带者中发生。我们研究了HTLV - 1携带者和HAM/TSP患者外周血单个核细胞中病毒基因组剂量与血清学反应之间的关系。随着病毒基因组剂量的增加，HTLV‐1 gag和env蛋白的抗体滴度以及病毒蛋白p40tax的抗体反应频率和滴度均增加。然而，异常淋巴细胞的数量与宿主病毒载量无直接关系。HAM/TSP患者通常表现出比健康携带者更高的基因组剂量，并且具有更高的抗体滴度，具有相同HTLV‐1载量的健康携带者，支持这些患者中存在增强的免疫反应。这些发现表明，HTLV‐1基因组产物的抗体滴度，而不是异常淋巴细胞的数量，密切反映了HTLV‐1感染个体的大致病毒载量。
Two distinct diseases, adult T‐cell leukemia (ATL) and HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP), develop in a minor population of HTLV‐1 carriers. We examined the relationship between the viral genome dose in the peripheral‐blood mononuclear cells and the serological response in HTLV‐1 carriers and patients with HAM/TSP. The antibody titer to HTLV‐1 gag and env proteins, as well as the frequency of an antibody response to viral protein p40tax and the titer, increased with increasing viral genome dose. However, the number of abnormal lymphocytes was not directly related to the host viral load. Patients with HAM/TSP generally showed a higher genome dose than healthy carriers and also had higher antibody titers than healthy carriers with the same HTLV‐1 load, supporting the existence of an augmented immune response in these patients. These findings suggest that the antibody titer to HTLV‐1 genome products, and not the number of abnormal lymphocytes, intimately reflects the approximate viral load in HTLV‐I ‐infected individuals.
人类 T 细胞白血病病毒 I 型的性传播与抗 Tax 抗体的存在有关。
DOI：
10.1073/pnas.88.4.1182
发表时间：
1991
影响因子：
11.1
作者：
Chen,YM;Okayama,A;Lee,TH;Tachibana,N;Mueller,N;Essex,M
通讯作者：
Essex,M