Follicular lymphoma: too many reminders for a memory B cell.
Follicular lymphoma: too many reminders for a memory B cell.
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滤泡性淋巴瘤：记忆B细胞的提醒太多。
DOI：
10.1172/jci79189
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Müschen,Markus
中科院分区：
文献类型：
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作者：
Swaminathan,Srividya;Müschen,Markus
记忆B细胞是成熟B细胞群的一个动态子集，在某些情况下可以在反复感染的情况下重新进入生发中心（GCs）。这种再激活可能导致这些细胞中遗传病变的积累，可能是B细胞突变酶AID的重复激活。正常记忆B细胞不能在反复进入GCs后存活。在这期杂志上，Sungalee等人证明，携带致癌基因BCL2: igh易位的记忆B细胞，导致组成性BCL2表达，在重复免疫多次GC进入后存活下来。通过这些多次GC再入，bcl2: igh易位使得艾滋病诱导的高突变和向恶性滤泡性淋巴瘤的克隆进化得以传播。
Memory B cells are a dynamic subset of the mature B cell population that in some cases can reenter germinal centers (GCs) in response to iterative infections. Such a reactivation can lead to accumulation of genetic lesions in these cells, potentially from repetitive activation of the B cell mutator enzyme AID. Normal memory B cells do not survive repeated reentries into GCs. In this issue, Sungalee et al. demonstrate that memory B cells harboring the oncogenicBCL2:IGHtranslocation, which results in constitutive BCL2 expression, survive multiple GC entries upon repetitive immunization. Through these multiple GC reentries, the hallmarkBCL2:IGHtranslocation enables AID-induced hypermutation and propagates clonal evolution toward malignant follicular lymphoma.